methyl 4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-phenylalaninate

Base Information

Chemical Name:methyl 4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-phenylalaninate
CAS No.:959993-00-1
Molecular Formula:C₂₁H₂₇N₃O₂
Molecular Weight:353.464
Hs Code.:

Synonyms:methyl 4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-phenylalaninate

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Chemical Property of methyl 4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-phenylalaninate

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Technology Process of methyl 4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-phenylalaninate

There total 4 articles about methyl 4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-phenylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 959992-99-5
methyl N-(tert-butoxycarbonyl)-4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-phenylalaninate

: 959993-00-1
methyl 4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-phenylalaninate

Guidance literature:: methyl N-(tert-butoxycarbonyl)-4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-phenylalaninate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

With ammonia; In methanol; dichloromethane; at 0 ℃;

Reference yield:

: 959992-96-2
2-prop-2-en-1-yl-1,8-naphthyridine

: 959993-00-1
methyl 4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-phenylalaninate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / palladium diacetate; tris-(o-tolyl)phosphine / acetonitrile / 0.33 h / 150 °C / Microwave irradiation

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 3000.3 Torr

3.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

3.2: 0 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium diacetate; palladium 10% on activated carbon; tris-(o-tolyl)phosphine; In ethanol; dichloromethane; acetonitrile;

Reference yield:

: 959992-97-3
methyl N-(tert-butoxycarbonyl)-4-[3-(1,8-naphthyridin-2-yl)prop-1-en-1-yl]-L-phenylalaninate

: 959993-00-1
methyl 4-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-phenylalaninate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 3000.3 Torr

2.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

2.2: 0 °C

With hydrogen; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane;