1-(4-fluorophenyl)-2-[(2S,4S)-4-isopropyl-3-tosyloxazolidin-2-yl]ethanone

Base Information

Chemical Name:1-(4-fluorophenyl)-2-[(2S,4S)-4-isopropyl-3-tosyloxazolidin-2-yl]ethanone
CAS No.:1297605-76-5
Molecular Formula:C₂₁H₂₄FNO₄S
Molecular Weight:405.49
Hs Code.:

Synonyms:1-(4-fluorophenyl)-2-[(2S,4S)-4-isopropyl-3-tosyloxazolidin-2-yl]ethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-fluorophenyl)-2-[(2S,4S)-4-isopropyl-3-tosyloxazolidin-2-yl]ethanone

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Technology Process of 1-(4-fluorophenyl)-2-[(2S,4S)-4-isopropyl-3-tosyloxazolidin-2-yl]ethanone

There total 4 articles about 1-(4-fluorophenyl)-2-[(2S,4S)-4-isopropyl-3-tosyloxazolidin-2-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 139192-48-6
(S)-N-(1-hydroxy-3-methylbutan-2-yl)-4-methylbenzenesulfonamide

: 54012-23-6
1-(4-fluorophenyl)prop-2-yn-1-one

: 1297605-76-5
1-(4-fluorophenyl)-2-[(2S,4S)-4-isopropyl-3-tosyloxazolidin-2-yl]ethanone

Guidance literature:: With 1,3-bis-(diphenylphosphino)propane; In acetonitrile; at 82 ℃; Inert atmosphere;
DOI:10.3390/molecules16053802

Reference yield:

: 1220-80-0,67368-40-5,150614-61-2
(S)-4-methyl-2-(toluene-4-sulfonamido)pentanoic acid

: 1297605-76-5
1-(4-fluorophenyl)-2-[(2S,4S)-4-isopropyl-3-tosyloxazolidin-2-yl]ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride

2: 1,3-bis-(diphenylphosphino)propane / acetonitrile / 82 °C / Inert atmosphere

With lithium aluminium tetrahydride; 1,3-bis-(diphenylphosphino)propane; In acetonitrile; 2: Michael reaction;
DOI:10.3390/molecules16053802

Reference yield:

: 3798-61-6,179249-16-2
1-(4-fluorophenyl)prop-2-yn-1-ol

: 1297605-76-5
1-(4-fluorophenyl)-2-[(2S,4S)-4-isopropyl-3-tosyloxazolidin-2-yl]ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: chromium(VI) oxide; sulfuric acid / water; acetone / 8 h / 0 - 22 °C

2: 1,3-bis-(diphenylphosphino)propane / acetonitrile / 82 °C / Inert atmosphere

With chromium(VI) oxide; sulfuric acid; 1,3-bis-(diphenylphosphino)propane; In water; acetone; acetonitrile; 2: Michael reaction;
DOI:10.3390/molecules16053802