(22R)-3β-acetoxy-22-tert-butyldimethylsilyloxy-16β-(4-nitrobenzoyloxy)cholesta-5,17(20)-diene

Base Information

Chemical Name:(22R)-3β-acetoxy-22-tert-butyldimethylsilyloxy-16β-(4-nitrobenzoyloxy)cholesta-5,17(20)-diene
CAS No.:695226-31-4
Molecular Formula:C₄₂H₆₃NO₇Si
Molecular Weight:722.05
Hs Code.:

Synonyms:(22R)-3β-acetoxy-22-tert-butyldimethylsilyloxy-16β-(4-nitrobenzoyloxy)cholesta-5,17(20)-diene

Suppliers and Price of (22R)-3β-acetoxy-22-tert-butyldimethylsilyloxy-16β-(4-nitrobenzoyloxy)cholesta-5,17(20)-diene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (22R)-3β-acetoxy-22-tert-butyldimethylsilyloxy-16β-(4-nitrobenzoyloxy)cholesta-5,17(20)-diene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (22R)-3β-acetoxy-22-tert-butyldimethylsilyloxy-16β-(4-nitrobenzoyloxy)cholesta-5,17(20)-diene

There total 11 articles about (22R)-3β-acetoxy-22-tert-butyldimethylsilyloxy-16β-(4-nitrobenzoyloxy)cholesta-5,17(20)-diene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 695226-23-4
(22R)-3β-acetoxy-22-tert-butyldimethylsilyloxycholesta-5,17(20)-diene-16β-ol

: 62-23-7
4-nitro-benzoic acid

: 695226-31-4
(22R)-3β-acetoxy-22-tert-butyldimethylsilyloxy-16β-(4-nitrobenzoyloxy)cholesta-5,17(20)-diene

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1081/SCC-120028627

Reference yield:

: 321125-15-9
(22β)-3β-hydroxyfurost-5-ene

: 695226-31-4
(22R)-3β-acetoxy-22-tert-butyldimethylsilyloxy-16β-(4-nitrobenzoyloxy)cholesta-5,17(20)-diene

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / 14 h / 20 °C

2: 413 mg / potassium dichromate; glacial acetic acid / 10 h / 70 °C

3: 71 percent / HClO₄; acetic anhydride / benzene / 0.5 h

4: 84 percent / meta-chloroperbenzoic acid / CH₂Cl₂ / 1 h

5: 75 percent / NaBH₄ / methanol / 0.5 h / 20 °C

6: 94.4 percent / imidazole / CH₂Cl₂; dimethylformamide / 1 h / 20 °C

7: 45 percent / 4-(dimethylamino)pyridine; dicyclohexylcarbodiimide / CH₂Cl₂ / 24 h / 20 °C

With pyridine; 1H-imidazole; dmap; potassium dichromate; sodium tetrahydroborate; perchloric acid; acetic anhydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1081/SCC-120028627

Reference yield:

: 439917-15-4
(22β,25R)-3β,26-dihydroxyfurost-5-en-3β-acetate

: 695226-31-4
(22R)-3β-acetoxy-22-tert-butyldimethylsilyloxy-16β-(4-nitrobenzoyloxy)cholesta-5,17(20)-diene

Guidance literature:: Multi-step reaction with 9 steps

1: 90 percent / 4-(dimethylamino)pyridine; pyridine / CH₂Cl₂ / 12 h / 20 °C

2: 78 percent / LiAlH₄ / tetrahydrofuran / 7 h / 20 °C

3: pyridine / 14 h / 20 °C

4: 413 mg / potassium dichromate; glacial acetic acid / 10 h / 70 °C

5: 71 percent / HClO₄; acetic anhydride / benzene / 0.5 h

6: 84 percent / meta-chloroperbenzoic acid / CH₂Cl₂ / 1 h

7: 75 percent / NaBH₄ / methanol / 0.5 h / 20 °C

8: 94.4 percent / imidazole / CH₂Cl₂; dimethylformamide / 1 h / 20 °C

9: 45 percent / 4-(dimethylamino)pyridine; dicyclohexylcarbodiimide / CH₂Cl₂ / 24 h / 20 °C

With pyridine; 1H-imidazole; dmap; potassium dichromate; sodium tetrahydroborate; lithium aluminium tetrahydride; perchloric acid; acetic anhydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1081/SCC-120028627