Technology Process of (22R)-3β-acetoxy-16β-4-nitrobenzoyloxycholesta-5,17(20)-diene-22-ol
There total 13 articles about (22R)-3β-acetoxy-16β-4-nitrobenzoyloxycholesta-5,17(20)-diene-22-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridinium p-toluenesulfonate;
In
methanol; dichloromethane;
at 20 ℃;
for 20h;
DOI:10.1081/SCC-120028627
- Guidance literature:
-
Multi-step reaction with 8 steps
1: pyridine / 14 h / 20 °C
2: 413 mg / potassium dichromate; glacial acetic acid / 10 h / 70 °C
3: 71 percent / HClO4; acetic anhydride / benzene / 0.5 h
4: 84 percent / meta-chloroperbenzoic acid / CH2Cl2 / 1 h
5: 75 percent / NaBH4 / methanol / 0.5 h / 20 °C
6: 94.4 percent / imidazole / CH2Cl2; dimethylformamide / 1 h / 20 °C
7: 45 percent / 4-(dimethylamino)pyridine; dicyclohexylcarbodiimide / CH2Cl2 / 24 h / 20 °C
8: 43 percent / pyridinium p-toluenesulfonate / methanol; CH2Cl2 / 20 h / 20 °C
With
pyridine; 1H-imidazole; dmap; potassium dichromate; sodium tetrahydroborate; perchloric acid; pyridinium p-toluenesulfonate; acetic anhydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide;
In
methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1081/SCC-120028627
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 90 percent / 4-(dimethylamino)pyridine; pyridine / CH2Cl2 / 12 h / 20 °C
2: 78 percent / LiAlH4 / tetrahydrofuran / 7 h / 20 °C
3: pyridine / 14 h / 20 °C
4: 413 mg / potassium dichromate; glacial acetic acid / 10 h / 70 °C
5: 71 percent / HClO4; acetic anhydride / benzene / 0.5 h
6: 84 percent / meta-chloroperbenzoic acid / CH2Cl2 / 1 h
7: 75 percent / NaBH4 / methanol / 0.5 h / 20 °C
8: 94.4 percent / imidazole / CH2Cl2; dimethylformamide / 1 h / 20 °C
9: 45 percent / 4-(dimethylamino)pyridine; dicyclohexylcarbodiimide / CH2Cl2 / 24 h / 20 °C
10: 43 percent / pyridinium p-toluenesulfonate / methanol; CH2Cl2 / 20 h / 20 °C
With
pyridine; 1H-imidazole; dmap; potassium dichromate; sodium tetrahydroborate; lithium aluminium tetrahydride; perchloric acid; pyridinium p-toluenesulfonate; acetic anhydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1081/SCC-120028627
