2-bromo-4-(4-acetyl-3-hydroxy-2-propylphenoxy)methylbenzoic acid

Base Information

• Chemical Name: 2-bromo-4-(4-acetyl-3-hydroxy-2-propylphenoxy)methylbenzoic acid
• CAS No.: 87808-18-2
• Molecular Formula: C₁₉H₁₉BrO₅
• Molecular Weight: 407.261
• Mol file: 87808-18-2.mol

Synonyms:2-bromo-4-(4-acetyl-3-hydroxy-2-propylphenoxy)methylbenzoic acid

Chemical Property of 2-bromo-4-(4-acetyl-3-hydroxy-2-propylphenoxy)methylbenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-bromo-4-(4-acetyl-3-hydroxy-2-propylphenoxy)methylbenzoic acid

There total 4 articles about 2-bromo-4-(4-acetyl-3-hydroxy-2-propylphenoxy)methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(4-acetyl-3-hydroxy-2-propylphenoxy)methyl] benzoic acid (87807-96-3) + 2-bromo-4-methylbenzoic acid (7697-27-0) → 2-bromo-4-(4-acetyl-3-hydroxy-2-propylphenoxy)methylbenzoic acid (87808-18-2)

Guidance literature:

In methanol;

Reference yield:

4-(4-Acetyl-3-hydroxy-2-propyl-phenoxymethyl)-2-bromo-benzoic acid methyl ester → 2-bromo-4-(4-acetyl-3-hydroxy-2-propylphenoxy)methylbenzoic acid (87808-18-2)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; water; Ambient temperature;

DOI:10.1021/jm00124a014

Reference yield:

1-(2,4-dihydroxy-3-propylphenyl)ethanone (40786-69-4) → 2-bromo-4-(4-acetyl-3-hydroxy-2-propylphenoxy)methylbenzoic acid (87808-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetone / Heating

2: LiOH*H₂O / tetrahydrofuran; methanol; H₂O / Ambient temperature

With lithium hydroxide; potassium carbonate; In tetrahydrofuran; methanol; water; acetone;

DOI:10.1021/jm00124a014

upstream raw materials:

1-(2,4-dihydroxy-3-propylphenyl)ethanone

methyl 2-bromo-4-(bromomethyl)benzoate

4-[(4-acetyl-3-hydroxy-2-propylphenoxy)methyl] benzoic acid

2-bromo-4-methylbenzoic acid