40786-69-4

Basic information

• Product Name: 2',4'-DIHYDROXY-3'-PROPYLACETOPHENONE
• Synonyms: 1-(2,4-DIHYDROXY-3-PROPYLPHENYL)ETHAN-1-ONE;2',4'-DIHYDROXY-3'-PROPYLACETOPHENONE;2',4'-DIHYDROXY-3'-PROPYLACETOPHENONE, 9 9%;(2,4-Dihydroxy-3-n-propylphenyl)ethanone;2',4'-Dihydroxy-3'-pyopylacetophene;Dihydroxy-3'-Propylacetophenone;1-(2,4-dihydroxy-3-propylphenyl)ethanone;4-dihydroxy-3-propylphenyl)-
• CAS NO: 40786-69-4
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.23
• Product Categories: Polymer Additives;Polymer Science;Stabilizers
• Mol File: 40786-69-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 124-127 °C(lit.)
• Boiling Point: 360.953 °C at 760 mmHg
• Flash Point: 186.286 °C
• Appearance: /
• Density: 1.162 g/cm³
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 8.49±0.23(Predicted)
• CAS DataBase Reference: 2',4'-DIHYDROXY-3'-PROPYLACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2',4'-DIHYDROXY-3'-PROPYLACETOPHENONE(40786-69-4)
• EPA Substance Registry System: 2',4'-DIHYDROXY-3'-PROPYLACETOPHENONE(40786-69-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 40786-69-4(Hazardous Substances Data)

Usage

Uses

1-(2,4-Dihydroxy-3-propylphenyl)ethanone is a reactant used in the synthesis of 2’-hydroxychalcones which affect cell growth inihibition , initiates apoptosis in human tumor cell lines.

Preparation

Preparation by reaction of acetonitrile on 2-propylresorcinol (Hoesch reaction) (86%).

Upstream product

• 40815-74-5 4-allyloxy-2-hydroxyacetophenone 
• 1616-54-2 8-allyl-7-hydroxy-4-methylcoumarin 
• 38987-00-7 2,4-dihydroxy-3-allylacetophenone 
• 64-17-5 ethanol 
• 16929-64-9 1,3-Dimethoxy-2-(prop-1'-yl)benzene 
• 1746-89-0 2-allyl-1,3-dihydroxybenzene 
• 13331-19-6 2-propyl-1,3-benzenediol 
• 75-36-5 acetyl chloride 
• 75-05-8 acetonitrile 

Downstream Products

• 92518-06-4 2'-Hydroxy-3'-(n-propyl)-4'-(4-bromobutoxy)-acetophenone 
• 92518-31-5 4-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-butyronitrile 
• 106627-20-7 6-(4-Acetyl-3-hydroxy-2-propylphenoxy)-1-hexanol 
• 106627-34-3 4'-<(8-bromooctyl)oxy>-3'-propyl-2'-hydroxyacetophenone 
• 79557-82-7 1-[4-(9-Bromo-nonyloxy)-2-hydroxy-3-propyl-phenyl]-ethanone 
• 106627-36-5 1-[4-(12-Bromo-dodecyloxy)-2-hydroxy-3-propyl-phenyl]-ethanone 
• 92518-30-4 6-(4-acetyl-3-hydroxy-2-propylphenoxy)hexane nitrile 
• 88420-31-9 4-(4-acetyl-3-hydroxy-2-propylphenoxy)-butanoic acid ethyl ester 
• 88420-36-4 6-(4-acetyl-3-hydroxy-2-propylphenoxy)-hexanoic acid methyl ester 
• 87807-95-2 4-[(4-Acetyl-3-hydroxy-2-propylphenoxy)-methyl]benzoic acid methyl ester 
• 104835-58-7 {7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propoxy]-naphthalen-2-yloxy}-acetic acid methyl ester 
• 104835-59-8 4-{7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propoxy]-naphthalen-2-yloxy}-butyric acid methyl ester 
• 101463-94-9 <<8-acetyl-7-<3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy>-2-naphthalenyl>oxy>acetic acid methyl ester 
• 88420-23-9 [4-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]-2-propylphenoxy]acetic acid ethyl ester 

Relevant articles and documents

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 1: Identification and synthesis of phenyl-tetrazolyl acetophenones

We have identified and synthesized a series of aryl-tetrazoyl acetophenones as positive allosteric potentiators of the metabotropic glutamate receptor 2. Structure activity relationship studies directed toward improving the potency and level of potentiation led to the discovery of 22 (EC50 = 93 nM, 128% potentiation). We have identified and synthesized a series of aryl-tetrazoyl acetophenones as positive allosteric potentiators of the metabotropic glutamate receptor 2. Structure activity relationship studies directed toward improving the potency and level of potentiation led to the discovery of 22 (EC50 = 93 nM, 128% potentiation).

STEREOSELECTIVE SYNTHESIS OF LEUKOTRIENE ANTAGONISTS

The present invention relates to a stereo-selective synthesis of leukotriene antagonists. More particularly, this invention relates to the stereo-selective synthesis of (βS,γR) and (βR,γS)-4-((3-(4-acetyl-3-hydroxy-2-propyl(phenoxy)propyl)-thio-γ-hydroxy-

Stereoselective synthesis of leukotriene antagonists

The present invention relates to a stereo-selective synthesis of leukotriene antagonists. More particularly, this invention relates to the stereo-selective synthesis of (βS,γR) and (βR,γS)--4-((3-(4-acetyl-3-hydroxy-2-propyl(phenoxy)propyl)-thio)-γ-hydroxy-β-methylbenzenebutanoic acid, and related compounds. These compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders, inflammation and pain in mammals, especially humans. The compounds are also useful for inducing cytoprotection in mammals, especially humans.