(S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoate

Base Information

Chemical Name:(S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoate
CAS No.:1609191-17-4
Molecular Formula:C₃₂H₃₇N₃O₆
Molecular Weight:559.662
Hs Code.:

Synonyms:(S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoate

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Chemical Property of (S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoate

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Technology Process of (S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoate

There total 3 articles about (S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1561822-63-6
2-amino-1-(2-methoxyquinolin-3-yl)ethanone

: 1609191-16-3
(S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-8-((2-(2-methoxyquinolin-3-yl)-2-oxoethyl)amino)-8-oxooctanoate

: 1609191-17-4
(S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoate

Guidance literature:: 2-amino-1-(2-methoxyquinolin-3-yl)ethanone; With hexachloroethane; triethylamine; triphenylphosphine; In dichloromethane; at 20 ℃; for 0.0833333h;

(S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-8-((2-(2-methoxyquinolin-3-yl)-2-oxoethyl)amino)-8-oxooctanoate; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 6931-16-4
2-methoxy-quinoline

: 1609191-17-4
(S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,4,6-trimethylphenyl bromide; n-butyllithium / tetrahydrofuran / 1.17 h / 0 °C

1.2: 0.5 h / -78 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

3.1: triethylamine; triphenylphosphine; hexachloroethane / dichloromethane / 0.08 h / 20 °C

3.2: 1 h / 20 °C

With hydrogenchloride; n-butyllithium; hexachloroethane; 2,4,6-trimethylphenyl bromide; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 1561822-61-4
tert-butyl (2-(2-methoxyquinolin-3-yl)-2-oxoethyl)carbamate

: 1609191-17-4
(S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

2.1: triethylamine; triphenylphosphine; hexachloroethane / dichloromethane / 0.08 h / 20 °C

2.2: 1 h / 20 °C

With hydrogenchloride; hexachloroethane; triethylamine; triphenylphosphine; In 1,4-dioxane; dichloromethane;