(S)-7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoic acid

Base Information

Chemical Name:(S)-7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoic acid
CAS No.:1609191-18-5
Molecular Formula:C₂₈H₂₉N₃O₆
Molecular Weight:503.555
Hs Code.:

Synonyms:(S)-7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoic acid

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Chemical Property of (S)-7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoic acid

Chemical Property:

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Technology Process of (S)-7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoic acid

There total 4 articles about (S)-7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609191-17-4
(S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoate

: 1609191-18-5
(S)-7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 72h;

Reference yield:

: 1561822-63-6
2-amino-1-(2-methoxyquinolin-3-yl)ethanone

: 1609191-18-5
(S)-7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; triphenylphosphine; hexachloroethane / dichloromethane / 0.08 h / 20 °C

1.2: 1 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 72 h / 0 °C

With hexachloroethane; triethylamine; triphenylphosphine; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 6931-16-4
2-methoxy-quinoline

: 1609191-18-5
(S)-7-(((benzyloxy)carbonyl)amino)-7-(5-(2-methoxyquinolin-3-yl)oxazol-2-yl)heptanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,4,6-trimethylphenyl bromide; n-butyllithium / tetrahydrofuran / 1.17 h / 0 °C

1.2: 0.5 h / -78 °C

2.1: hydrogenchloride / 1,4-dioxane / 1 h / 0 - 20 °C

3.1: triethylamine; triphenylphosphine; hexachloroethane / dichloromethane / 0.08 h / 20 °C

3.2: 1 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 72 h / 0 °C

With hydrogenchloride; n-butyllithium; hexachloroethane; 2,4,6-trimethylphenyl bromide; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane;