4-((4-(4-chloroquinazolin-6-yl)phenyl)sulfonyl)morpholine hydrochloride

Base Information

Chemical Name:4-((4-(4-chloroquinazolin-6-yl)phenyl)sulfonyl)morpholine hydrochloride
CAS No.:1432451-00-7
Molecular Formula:C₁₈H₁₆ClN₃O₃S*ClH
Molecular Weight:426.323
Hs Code.:

Synonyms:4-((4-(4-chloroquinazolin-6-yl)phenyl)sulfonyl)morpholine hydrochloride

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Chemical Property of 4-((4-(4-chloroquinazolin-6-yl)phenyl)sulfonyl)morpholine hydrochloride

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Technology Process of 4-((4-(4-chloroquinazolin-6-yl)phenyl)sulfonyl)morpholine hydrochloride

There total 4 articles about 4-((4-(4-chloroquinazolin-6-yl)phenyl)sulfonyl)morpholine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1432450-99-1
6-(4-(morpholinosulfonyl)phenyl)quinazolin-4(3H)-one

: 1432451-00-7
4-((4-(4-chloroquinazolin-6-yl)phenyl)sulfonyl)morpholine hydrochloride

Guidance literature:: With thionyl chloride; In N,N-dimethyl-formamide; at 80 ℃; for 36h;
DOI:10.1021/jm400349k

Reference yield:

: 5326-47-6
2-amino-5-iodobenzoic acid

: 1432451-00-7
4-((4-(4-chloroquinazolin-6-yl)phenyl)sulfonyl)morpholine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 4 h / 170 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 30 h / 80 °C

3: thionyl chloride / N,N-dimethyl-formamide / 36 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400349k

Reference yield:

: 16064-08-7
6-iodoquinazolin-4(3H)-one

: 1432451-00-7
4-((4-(4-chloroquinazolin-6-yl)phenyl)sulfonyl)morpholine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 30 h / 80 °C

2: thionyl chloride / N,N-dimethyl-formamide / 36 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400349k