S-2,2,2-trifluoroethyl 3,4-dimethoxyphenylthioacetate

Base Information

• Chemical Name: S-2,2,2-trifluoroethyl 3,4-dimethoxyphenylthioacetate
• CAS No.: 1309379-76-7
• Molecular Formula: C₁₂H₁₃F₃O₃S
• Molecular Weight: 294.295
• Mol file: 1309379-76-7.mol

Synonyms:S-2,2,2-trifluoroethyl 3,4-dimethoxyphenylthioacetate

Chemical Property of S-2,2,2-trifluoroethyl 3,4-dimethoxyphenylthioacetate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of S-2,2,2-trifluoroethyl 3,4-dimethoxyphenylthioacetate

There total 1 articles about S-2,2,2-trifluoroethyl 3,4-dimethoxyphenylthioacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(3,4-Dimethoxyphenyl)acetic acid (93-40-3) + 2,2,2-trifluoroethanethiol (1544-53-2) → S-2,2,2-trifluoroethyl 3,4-dimethoxyphenylthioacetate (1309379-76-7)

Guidance literature:

(3,4-Dimethoxyphenyl)acetic acid; With benzotriazol-1-ol; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

2,2,2-trifluoroethanethiol; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/adsc.201100122

Reference yield:

S-2,2,2-trifluoroethyl 3,4-dimethoxyphenylthioacetate (1309379-76-7) + benzaldehyde (100-52-7) → S-2,2,2-trifluoroethyl (2S,3R)-2-(3,4-dimethoxyphenyl)-3-hydroxy-3-phenylpropanethioate + C19H19F3O4S

Guidance literature:

With tetrachlorosilane; C₃₅H₃₀O₂P₂S₂; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 15h; Overall yield = 57 percent;

DOI:10.1055/s-0039-1690777

Reference yield:

S-2,2,2-trifluoroethyl 3,4-dimethoxyphenylthioacetate (1309379-76-7) + benzaldehyde (100-52-7) → S-2,2,2-trifluoroethyl (2S,3R)-2-(3,4-dimethoxyphenyl)-3-hydroxy-3-phenylpropanethioate + S-2,2,2-trifluoroethyl (2R,3S)-2-(3,4-dimethoxyphenyl)-3-hydroxy-3-phenylpropanethioate + S-2,2,2-trifluoroethyl (2R,3R)-2-(3,4-dimethoxyphenyl)-3-hydroxy-3-phenylpropanethioate (1309379-90-5)

Guidance literature:

S-2,2,2-trifluoroethyl 3,4-dimethoxyphenylthioacetate; With tetrachlorosilane; (S)-2,2',5,5'-tetramethyl-4,4'-bis-(diphenylphoshino)-3,3'-bithiophene oxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;

benzaldehyde; In dichloromethane; at 0 ℃; for 15h; optical yield given as %ee; stereoselective reaction; Inert atmosphere;

DOI:10.1002/adsc.201100122

upstream raw materials:

(3,4-Dimethoxyphenyl)acetic acid

2,2,2-trifluoroethanethiol

Downstream raw materials:

S-2,2,2-trifluoroethyl (2R,3R)-2-(3,4-dimethoxyphenyl)-3-hydroxy-3-phenylpropanethioate