tert-butyl 4-(2-(3-(4-fluoro-2-methylphenoxy)-5-(3-methoxyphenylthio)pyridin-2-ylamino)thiazol-4-yl)piperidine-1-carboxylate trifluoroacetate

Base Information

Chemical Name:tert-butyl 4-(2-(3-(4-fluoro-2-methylphenoxy)-5-(3-methoxyphenylthio)pyridin-2-ylamino)thiazol-4-yl)piperidine-1-carboxylate trifluoroacetate
CAS No.:953045-87-9
Molecular Formula:C₂HF₃O₂*C₃₂H₃₅FN₄O₄S₂
Molecular Weight:736.809
Hs Code.:

tert-butyl 4-(2-(3-(4-fluoro-2-methylphenoxy)-5-(3-methoxyphenylthio)pyridin-2-ylamino)thiazol-4-yl)piperidine-1-carboxylate trifluoroacetate

Synonyms:tert-butyl 4-(2-(3-(4-fluoro-2-methylphenoxy)-5-(3-methoxyphenylthio)pyridin-2-ylamino)thiazol-4-yl)piperidine-1-carboxylate trifluoroacetate

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Chemical Property of tert-butyl 4-(2-(3-(4-fluoro-2-methylphenoxy)-5-(3-methoxyphenylthio)pyridin-2-ylamino)thiazol-4-yl)piperidine-1-carboxylate trifluoroacetate

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Technology Process of tert-butyl 4-(2-(3-(4-fluoro-2-methylphenoxy)-5-(3-methoxyphenylthio)pyridin-2-ylamino)thiazol-4-yl)piperidine-1-carboxylate trifluoroacetate

There total 10 articles about tert-butyl 4-(2-(3-(4-fluoro-2-methylphenoxy)-5-(3-methoxyphenylthio)pyridin-2-ylamino)thiazol-4-yl)piperidine-1-carboxylate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 953045-85-7
tert-butyl 4-(2-(3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio)pyridin-2-ylamino)thiazol-4-yl)piperidine-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 74-88-4
methyl iodide

: 953045-87-9
tert-butyl 4-(2-(3-(4-fluoro-2-methylphenoxy)-5-(3-methoxyphenylthio)pyridin-2-ylamino)thiazol-4-yl)piperidine-1-carboxylate trifluoroacetate

Guidance literature:: tert-butyl 4-(2-(3-(2-bromo-4-fluorophenoxy)-5-(3-methoxyphenylthio)pyridin-2-ylamino)thiazol-4-yl)piperidine-1-carboxylate; With methyllithium; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

trifluoroacetic acid; methyl iodide; more than 3 stages;

Reference yield:

: 573675-25-9
5-bromo-3-nitropyridine-2-carbonitrile

: 953045-87-9
tert-butyl 4-(2-(3-(4-fluoro-2-methylphenoxy)-5-(3-methoxyphenylthio)pyridin-2-ylamino)thiazol-4-yl)piperidine-1-carboxylate trifluoroacetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C

1.2: 0.33 h / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.1: potassium hydroxide; water / ethanol / Heating / reflux

3.2: 20 °C

4.1: diphenyl phosphoryl azide; triethylamine / toluene / 0.17 h / 100 °C

5.1: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 20 °C

6.1: tetrahydrofuran / 20 °C

7.1: sodium hydroxide / ethanol / 50 °C

8.1: triethylamine / ethanol / 2 h / 70 °C

9.1: methyllithium / tetrahydrofuran / 0.08 h / -78 °C

9.2: 0.08 h / -78 °C

With hydrogenchloride; potassium hydroxide; sodium hydroxide; diphenyl phosphoryl azide; water; methyllithium; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1065609-78-0
5-bromo-3-(2-bromo-4-fluorophenoxy)picolinonitrile

: 953045-87-9
tert-butyl 4-(2-(3-(4-fluoro-2-methylphenoxy)-5-(3-methoxyphenylthio)pyridin-2-ylamino)thiazol-4-yl)piperidine-1-carboxylate trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.1: potassium hydroxide; water / ethanol / Heating / reflux

2.2: 20 °C

3.1: diphenyl phosphoryl azide; triethylamine / toluene / 0.17 h / 100 °C

4.1: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 20 °C

5.1: tetrahydrofuran / 20 °C

6.1: sodium hydroxide / ethanol / 50 °C

7.1: triethylamine / ethanol / 2 h / 70 °C

8.1: methyllithium / tetrahydrofuran / 0.08 h / -78 °C

8.2: 0.08 h / -78 °C

With hydrogenchloride; potassium hydroxide; sodium hydroxide; diphenyl phosphoryl azide; water; methyllithium; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;