3-(4-methoxybenzoyl)-1-(4-nitrophenoxycarbonyl)-7-pyridin-4-ylindolizine

Base Information

• Chemical Name: 3-(4-methoxybenzoyl)-1-(4-nitrophenoxycarbonyl)-7-pyridin-4-ylindolizine
• CAS No.: 853268-95-8
• Molecular Formula: C₂₈H₁₉N₃O₆
• Molecular Weight: 493.475
• Mol file: 853268-95-8.mol

Synonyms:3-(4-methoxybenzoyl)-1-(4-nitrophenoxycarbonyl)-7-pyridin-4-ylindolizine

Chemical Property of 3-(4-methoxybenzoyl)-1-(4-nitrophenoxycarbonyl)-7-pyridin-4-ylindolizine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-methoxybenzoyl)-1-(4-nitrophenoxycarbonyl)-7-pyridin-4-ylindolizine

There total 3 articles about 3-(4-methoxybenzoyl)-1-(4-nitrophenoxycarbonyl)-7-pyridin-4-ylindolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

propynoic acid-4-nitrophenylester (35665-87-3) + 1-(2-(4-methoxyphenyl)-2-oxoethyl)-[4,4'-bipyridin]-1-ium bromide → 3-(4-methoxybenzoyl)-1-(4-nitrophenoxycarbonyl)-7-pyridin-4-ylindolizine (853268-95-8)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; triethylamine; at 0 ℃; for 48h;

DOI:10.1016/j.tet.2005.02.063

Reference yield:

4,4'-bipyridine (553-26-4) → 3-(4-methoxybenzoyl)-1-(4-nitrophenoxycarbonyl)-7-pyridin-4-ylindolizine (853268-95-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetone / 10 h / 40 °C

2: 57 percent / triethylamine; N-methylpyrrolidone / 48 h / 0 °C

With 1-methyl-pyrrolidin-2-one; triethylamine; In acetone;

DOI:10.1016/j.tet.2005.02.063

Reference yield:

2-Bromo-4'-methoxyacetophenone (2632-13-5) → 3-(4-methoxybenzoyl)-1-(4-nitrophenoxycarbonyl)-7-pyridin-4-ylindolizine (853268-95-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetone / 10 h / 40 °C

2: 57 percent / triethylamine; N-methylpyrrolidone / 48 h / 0 °C

With 1-methyl-pyrrolidin-2-one; triethylamine; In acetone;

DOI:10.1016/j.tet.2005.02.063

upstream raw materials:

propynoic acid-4-nitrophenylester

4,4'-bipyridine

2-Bromo-4'-methoxyacetophenone