2-Propynoic acid, 4-nitrophenyl ester

Base Information

• Chemical Name: 2-Propynoic acid, 4-nitrophenyl ester
• CAS No.: 35665-87-3
• Molecular Formula: C9H5NO4
• Molecular Weight: 191.143
• Mol file: 35665-87-3.mol

Synonyms:

Chemical Property of 2-Propynoic acid, 4-nitrophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propynoic acid, 4-nitrophenyl ester

There total 3 articles about 2-Propynoic acid, 4-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + Propiolic acid (471-25-0) → propynoic acid-4-nitrophenylester (35665-87-3)

Guidance literature:

4-nitro-phenol; Propiolic acid; With dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

With dmap; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jacs.7b06820

Reference yield: 50.0%

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + Propiolic acid (471-25-0) → propynoic acid-4-nitrophenylester (35665-87-3) + (E)-3-(4-Nitro-phenoxy)-acrylic acid 4-nitro-phenyl ester

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1080/00397910008087068

Reference yield:

→ propynoic acid-4-nitrophenylester (35665-87-3)

Guidance literature:

Propiolsaeure-chlorid in Bzl., 4-Nitro-phenol in NaOH;

upstream raw materials:

4-nitro-phenol

Propiolic acid

Downstream raw materials:

3-(benzoyl)-1-(4-nitrophenoxycarbonyl)-7-pyridin-4-ylindolizine

3-(4-methylbenzoyl)-1-(4-nitrophenoxycarbonyl)-7-pyridin-4-ylindolizine

3-(4-chlorobenzoyl)-1-(4-nitrophenoxycarbonyl)-7-pyridin-4-ylindolizine

3-(4-methoxybenzoyl)-1-(4-nitrophenoxycarbonyl)-7-pyridin-4-ylindolizine