methyl 1-(l-menthoxyacetyl)-2-oxoimidazolidine-4(S)-carboxylate

Base Information

• Chemical Name: methyl 1-(l-menthoxyacetyl)-2-oxoimidazolidine-4(S)-carboxylate
• CAS No.: 459454-28-5
• Molecular Formula: C₁₇H₂₈N₂O₅
• Molecular Weight: 340.42
• Mol file: 459454-28-5.mol

Synonyms:methyl 1-(l-menthoxyacetyl)-2-oxoimidazolidine-4(S)-carboxylate

Chemical Property of methyl 1-(l-menthoxyacetyl)-2-oxoimidazolidine-4(S)-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 1-(l-menthoxyacetyl)-2-oxoimidazolidine-4(S)-carboxylate

There total 2 articles about methyl 1-(l-menthoxyacetyl)-2-oxoimidazolidine-4(S)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl 3-benzyloxycarbonyl-1-(l-menthoxyacetyl)-2-oxoimidazolidine-4(S)-carboxylate (459454-24-1) → methyl 1-(l-menthoxyacetyl)-2-oxoimidazolidine-4(S)-carboxylate (459454-28-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 6h; under 35 Torr;

DOI:10.1023/A:1015061620557

Reference yield:

methyl 3-benzyloxycarbonyl-2-oxo-imidazolidine-4(S)-carboxylate (168399-08-4) → methyl 1-(l-menthoxyacetyl)-2-oxoimidazolidine-4(S)-carboxylate (459454-28-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / DMAP; pyridine / CH₂Cl₂ / 24 h / Heating

2: 94 percent / H₂ / 10 percent Pd/C / ethyl acetate / 6 h / 35 Torr

With pyridine; dmap; hydrogen; palladium on activated charcoal; In dichloromethane; ethyl acetate;

DOI:10.1023/A:1015061620557

Reference yield: 65.0%

rhodium(II) acetate dimer + methyl 1-(l-menthoxyacetyl)-2-oxoimidazolidine-4(S)-carboxylate (459454-28-5) → dirhodium(II) tetrakis[methyl 1-(l-menthoxyacetyl)-2-oxoimidazolidine-4(S)-carboxylate]

Guidance literature:

In chlorobenzene; the soln. in chlorobenzene was heated at reflux under N2 for about 22 h; solvent was evapd. at -20°C, the residue was dissolved in min CH3OH, filtered, chromd. on a column with Bakerbond Cyano 40 prep packing (CH3OH), recrystd. from CH3CN-CH3OH;

DOI:10.1023/A:1015061620557

upstream raw materials:

methyl 3-benzyloxycarbonyl-1-(l-menthoxyacetyl)-2-oxoimidazolidine-4(S)-carboxylate

methyl 3-benzyloxycarbonyl-2-oxo-imidazolidine-4(S)-carboxylate