N-[(1R)-1-cyclohexyl-4-hydroxy-4-methylpent-2-ynyl]-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-[(1R)-1-cyclohexyl-4-hydroxy-4-methylpent-2-ynyl]-4-methylbenzenesulfonamide
CAS No.:1342341-13-2
Molecular Formula:C₁₉H₂₇NO₃S
Molecular Weight:349.494
Hs Code.:

Synonyms:N-[(1R)-1-cyclohexyl-4-hydroxy-4-methylpent-2-ynyl]-4-methylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(1R)-1-cyclohexyl-4-hydroxy-4-methylpent-2-ynyl]-4-methylbenzenesulfonamide

Chemical Property:

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Technology Process of N-[(1R)-1-cyclohexyl-4-hydroxy-4-methylpent-2-ynyl]-4-methylbenzenesulfonamide

There total 4 articles about N-[(1R)-1-cyclohexyl-4-hydroxy-4-methylpent-2-ynyl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1342341-12-1
C₂₄H₃₅NO₅S

: 1342341-13-2
N-[(1R)-1-cyclohexyl-4-hydroxy-4-methylpent-2-ynyl]-4-methylbenzenesulfonamide

Guidance literature:: With hydrogenchloride; water; In ethyl acetate; at 50 ℃; for 9h;
DOI:10.1055/s-0030-1260098

Reference yield:

: 321855-40-7
(S)-1-cyclohexyl-4-methyl-pent-2-yne-1,4-diol

: 1342341-13-2
N-[(1R)-1-cyclohexyl-4-hydroxy-4-methylpent-2-ynyl]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Cooling

2: hydrogenchloride; water / ethyl acetate / 9 h / 50 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; water; triphenylphosphine; In tetrahydrofuran; ethyl acetate; 1: Mitsunobu reaction;
DOI:10.1055/s-0030-1260098

Reference yield:

: 2043-61-0
cyclohexanecarbaldehyde

: 1342341-13-2
N-[(1R)-1-cyclohexyl-4-hydroxy-4-methylpent-2-ynyl]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: (-)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine / toluene

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Cooling

3: hydrogenchloride; water / ethyl acetate / 9 h / 50 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; (-)-N-methylephedrine; water; zinc trifluoromethanesulfonate; triethylamine; triphenylphosphine; In tetrahydrofuran; ethyl acetate; toluene; 1: Carreira asymmetric alkylation / 2: Mitsunobu reaction;
DOI:10.1055/s-0030-1260098