2(R)-<<(1,1-Dimethylethoxy)carbonyl>amino>-2-<(3-hydroxy-4-methoxyphenyl)acetyl>-D-phenylalanine (methoxyethoxy)methyl ester

Base Information

Chemical Name:2(R)-<<(1,1-Dimethylethoxy)carbonyl>amino>-2-<(3-hydroxy-4-methoxyphenyl)acetyl>-D-phenylalanine (methoxyethoxy)methyl ester
CAS No.:159579-66-5
Molecular Formula:C₂₇H₃₆N₂O₉
Molecular Weight:532.591
Hs Code.:

Synonyms:2(R)-<<(1,1-Dimethylethoxy)carbonyl>amino>-2-<(3-hydroxy-4-methoxyphenyl)acetyl>-D-phenylalanine (methoxyethoxy)methyl ester

Suppliers and Price of 2(R)-<<(1,1-Dimethylethoxy)carbonyl>amino>-2-<(3-hydroxy-4-methoxyphenyl)acetyl>-D-phenylalanine (methoxyethoxy)methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2(R)-<<(1,1-Dimethylethoxy)carbonyl>amino>-2-<(3-hydroxy-4-methoxyphenyl)acetyl>-D-phenylalanine (methoxyethoxy)methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2(R)-<<(1,1-Dimethylethoxy)carbonyl>amino>-2-<(3-hydroxy-4-methoxyphenyl)acetyl>-D-phenylalanine (methoxyethoxy)methyl ester

There total 6 articles about 2(R)-<<(1,1-Dimethylethoxy)carbonyl>amino>-2-<(3-hydroxy-4-methoxyphenyl)acetyl>-D-phenylalanine (methoxyethoxy)methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 159579-65-4
N-<2(R)-Azido-2-<3-(benzyloxy)-4-methoxyphenyl>acetyl>-D-phenylalanine (methoxyethoxy)methyl ester

: 159579-66-5
2(R)-<<(1,1-Dimethylethoxy)carbonyl>amino>-2-<(3-hydroxy-4-methoxyphenyl)acetyl>-D-phenylalanine (methoxyethoxy)methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 48h;
DOI:10.1021/jo00088a010

Reference yield:

: 2448-45-5
Cbz-D-Phe

: 159579-66-5
2(R)-<<(1,1-Dimethylethoxy)carbonyl>amino>-2-<(3-hydroxy-4-methoxyphenyl)acetyl>-D-phenylalanine (methoxyethoxy)methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / Bu₄NI

2: 89 percent / H₂ / 10percent Pd-C / ethanol / 0.25 h

3: EDC, HOBT / CH₂Cl₂ / 1.) 0 deg C, 1.3 h, 2.) room temp., 20 min

4: 81 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 48 h

With hydrogen; tetra-(n-butyl)ammonium iodide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo00088a010

Reference yield:

: 673-06-3,25191-15-5,658-69-5,67675-33-6
D-(R)-phenylalanine

: 159579-66-5
2(R)-<<(1,1-Dimethylethoxy)carbonyl>amino>-2-<(3-hydroxy-4-methoxyphenyl)acetyl>-D-phenylalanine (methoxyethoxy)methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / aq. Na₂CO₃

2: 87 percent / Bu₄NI

3: 89 percent / H₂ / 10percent Pd-C / ethanol / 0.25 h

4: EDC, HOBT / CH₂Cl₂ / 1.) 0 deg C, 1.3 h, 2.) room temp., 20 min

5: 81 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 48 h

With hydrogen; tetra-(n-butyl)ammonium iodide; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jo00088a010