3-(N-((1R,2S)-1-(allyloxy)-1-phenylpropan-2-yl)-N-methylamino)propanenitrile

Base Information

Chemical Name:3-(N-((1R,2S)-1-(allyloxy)-1-phenylpropan-2-yl)-N-methylamino)propanenitrile
CAS No.:934022-49-8
Molecular Formula:C₁₆H₂₂N₂O
Molecular Weight:258.363
Hs Code.:

Synonyms:3-(N-((1R,2S)-1-(allyloxy)-1-phenylpropan-2-yl)-N-methylamino)propanenitrile

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Chemical Property of 3-(N-((1R,2S)-1-(allyloxy)-1-phenylpropan-2-yl)-N-methylamino)propanenitrile

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Technology Process of 3-(N-((1R,2S)-1-(allyloxy)-1-phenylpropan-2-yl)-N-methylamino)propanenitrile

There total 2 articles about 3-(N-((1R,2S)-1-(allyloxy)-1-phenylpropan-2-yl)-N-methylamino)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 106-95-6
allyl bromide

: 40682-75-5
3-(N-((1R,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methylamino)propanenitrile

: 934022-49-8
3-(N-((1R,2S)-1-(allyloxy)-1-phenylpropan-2-yl)-N-methylamino)propanenitrile

Guidance literature:: 3-(N-((1R,2S)-1-hydroxy-1-phenylpropan-2-yl)-N-methylamino)propanenitrile; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

allyl bromide; With tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; at 20 ℃; for 12h; Further stages.;
DOI:10.1016/j.tetlet.2007.01.047

Reference yield:

: 299-42-3,7009-81-6,90-83-5,6912-63-6
ephedrine

: 934022-49-8
3-(N-((1R,2S)-1-(allyloxy)-1-phenylpropan-2-yl)-N-methylamino)propanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: 97 percent / methanol

2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

2.2: 91 percent / tetrabutylammonium iodide / tetrahydrofuran / 12 h / 20 °C

With sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1016/j.tetlet.2007.01.047

Reference yield:

: 934022-49-8
3-(N-((1R,2S)-1-(allyloxy)-1-phenylpropan-2-yl)-N-methylamino)propanenitrile

: C₁₃H₁₉NO₂

Guidance literature:: With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -78 - 20 ℃;
DOI:10.1016/j.tetlet.2007.01.047