(4E,8E,12E,16Z)-18-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-4,8,12,16-tetramethyl-octadeca-4,8,12,16-tetraenoic acid ethyl ester

Base Information

Chemical Name:(4E,8E,12E,16Z)-18-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-4,8,12,16-tetramethyl-octadeca-4,8,12,16-tetraenoic acid ethyl ester
CAS No.:201004-77-5
Molecular Formula:C₄₃H₇₀O₆Si
Molecular Weight:711.111
Hs Code.:

(4E,8E,12E,16Z)-18-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-4,8,12,16-tetramethyl-octadeca-4,8,12,16-tetraenoic acid ethyl ester

Synonyms:(4E,8E,12E,16Z)-18-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-4,8,12,16-tetramethyl-octadeca-4,8,12,16-tetraenoic acid ethyl ester

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Chemical Property of (4E,8E,12E,16Z)-18-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-4,8,12,16-tetramethyl-octadeca-4,8,12,16-tetraenoic acid ethyl ester

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Technology Process of (4E,8E,12E,16Z)-18-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-4,8,12,16-tetramethyl-octadeca-4,8,12,16-tetraenoic acid ethyl ester

There total 6 articles about (4E,8E,12E,16Z)-18-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-4,8,12,16-tetramethyl-octadeca-4,8,12,16-tetraenoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 78-39-7
Triethyl orthoacetate

: 201004-76-4
(6E,10E,14Z)-16-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2,6,10,14-tetramethyl-hexadeca-1,6,10,14-tetraen-3-ol

: 201004-77-5
(4E,8E,12E,16Z)-18-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-4,8,12,16-tetramethyl-octadeca-4,8,12,16-tetraenoic acid ethyl ester

Guidance literature:: With propionic acid; at 140 ℃; for 1h;
DOI:10.1002/(SICI)1099-0690(199801)1998:1<43::AID-EJOC43>3.0.CO;2-L

Reference yield:

: 176246-20-1
(4E,8E,12E)-14-Acetoxy-4,8,12-trimethyl-tetradeca-4,8,12-trienoic acid methyl ester

: 201004-77-5
(4E,8E,12E,16Z)-18-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-4,8,12,16-tetramethyl-octadeca-4,8,12,16-tetraenoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / Pd(dba)2, LiCl / dimethylformamide

2: 95 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

3: Dess-Martin periodinane, pyridine / CH₂Cl₂ / 1 h / Ambient temperature

4: 70 percent / 1.) s-BuLi / tetrahydrofuran; cyclohexane / 1.) -78 deg C, 30 min; 2.) room temp., 2 h

5: 83 percent / propionic acid / 1 h / 140 °C

With pyridine; lithium aluminium tetrahydride; sec.-butyllithium; Dess-Martin periodane; propionic acid; lithium chloride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1002/(SICI)1099-0690(199801)1998:1<43::AID-EJOC43>3.0.CO;2-L

Reference yield:

: {2-[2,3-Dimethyl-4-(tetrahydro-pyran-2-yloxy)-6-trimethylstannanyl-phenoxymethoxy]-ethyl}-trimethyl-silane

: 201004-77-5
(4E,8E,12E,16Z)-18-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-4,8,12,16-tetramethyl-octadeca-4,8,12,16-tetraenoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / Pd(dba)2, LiCl / dimethylformamide

2: 95 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

3: Dess-Martin periodinane, pyridine / CH₂Cl₂ / 1 h / Ambient temperature

4: 70 percent / 1.) s-BuLi / tetrahydrofuran; cyclohexane / 1.) -78 deg C, 30 min; 2.) room temp., 2 h

5: 83 percent / propionic acid / 1 h / 140 °C

With pyridine; lithium aluminium tetrahydride; sec.-butyllithium; Dess-Martin periodane; propionic acid; lithium chloride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1002/(SICI)1099-0690(199801)1998:1<43::AID-EJOC43>3.0.CO;2-L