(6E,10E,14Z)-16-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2,6,10,14-tetramethyl-hexadeca-1,6,10,14-tetraen-3-ol

Base Information

Chemical Name:(6E,10E,14Z)-16-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2,6,10,14-tetramethyl-hexadeca-1,6,10,14-tetraen-3-ol
CAS No.:201004-76-4
Molecular Formula:C₃₉H₆₄O₅Si
Molecular Weight:641.02
Hs Code.:

(6E,10E,14Z)-16-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2,6,10,14-tetramethyl-hexadeca-1,6,10,14-tetraen-3-ol

Synonyms:(6E,10E,14Z)-16-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2,6,10,14-tetramethyl-hexadeca-1,6,10,14-tetraen-3-ol

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Chemical Property of (6E,10E,14Z)-16-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2,6,10,14-tetramethyl-hexadeca-1,6,10,14-tetraen-3-ol

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Technology Process of (6E,10E,14Z)-16-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2,6,10,14-tetramethyl-hexadeca-1,6,10,14-tetraen-3-ol

There total 5 articles about (6E,10E,14Z)-16-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2,6,10,14-tetramethyl-hexadeca-1,6,10,14-tetraen-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 557-93-7
2-bromoprop-1-ene

: 201004-75-3
(4E,8E,12Z)-14-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-4,8,12-trimethyl-tetradeca-4,8,12-trienal

: 201004-76-4
(6E,10E,14Z)-16-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2,6,10,14-tetramethyl-hexadeca-1,6,10,14-tetraen-3-ol

Guidance literature:: With sec.-butyllithium; In tetrahydrofuran; cyclohexane; 1.) -78 deg C, 30 min; 2.) room temp., 2 h;
DOI:10.1002/(SICI)1099-0690(199801)1998:1<43::AID-EJOC43>3.0.CO;2-L

Reference yield:

: 176246-20-1
(4E,8E,12E)-14-Acetoxy-4,8,12-trimethyl-tetradeca-4,8,12-trienoic acid methyl ester

: 201004-76-4
(6E,10E,14Z)-16-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2,6,10,14-tetramethyl-hexadeca-1,6,10,14-tetraen-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / Pd(dba)2, LiCl / dimethylformamide

2: 95 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

3: Dess-Martin periodinane, pyridine / CH₂Cl₂ / 1 h / Ambient temperature

4: 70 percent / 1.) s-BuLi / tetrahydrofuran; cyclohexane / 1.) -78 deg C, 30 min; 2.) room temp., 2 h

With pyridine; lithium aluminium tetrahydride; sec.-butyllithium; Dess-Martin periodane; lithium chloride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1002/(SICI)1099-0690(199801)1998:1<43::AID-EJOC43>3.0.CO;2-L

Reference yield:

: {2-[2,3-Dimethyl-4-(tetrahydro-pyran-2-yloxy)-6-trimethylstannanyl-phenoxymethoxy]-ethyl}-trimethyl-silane

: 201004-76-4
(6E,10E,14Z)-16-[3,4-Dimethyl-5-(tetrahydro-pyran-2-yloxy)-2-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-2,6,10,14-tetramethyl-hexadeca-1,6,10,14-tetraen-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / Pd(dba)2, LiCl / dimethylformamide

2: 95 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

3: Dess-Martin periodinane, pyridine / CH₂Cl₂ / 1 h / Ambient temperature

4: 70 percent / 1.) s-BuLi / tetrahydrofuran; cyclohexane / 1.) -78 deg C, 30 min; 2.) room temp., 2 h

With pyridine; lithium aluminium tetrahydride; sec.-butyllithium; Dess-Martin periodane; lithium chloride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1002/(SICI)1099-0690(199801)1998:1<43::AID-EJOC43>3.0.CO;2-L