benzyl 2-{[(3R)-3-benzyl-3-(2-nitrobenzenesulfonylamino)-2-oxo-azetidin-1-yl]-(R)-phenylacetamido}-2-methylpropanoate

Base Information

Chemical Name:benzyl 2-{[(3R)-3-benzyl-3-(2-nitrobenzenesulfonylamino)-2-oxo-azetidin-1-yl]-(R)-phenylacetamido}-2-methylpropanoate
CAS No.:923579-05-9
Molecular Formula:C₃₅H₃₄N₄O₈S
Molecular Weight:670.743
Hs Code.:

Synonyms:benzyl 2-{[(3R)-3-benzyl-3-(2-nitrobenzenesulfonylamino)-2-oxo-azetidin-1-yl]-(R)-phenylacetamido}-2-methylpropanoate

Suppliers and Price of benzyl 2-{[(3R)-3-benzyl-3-(2-nitrobenzenesulfonylamino)-2-oxo-azetidin-1-yl]-(R)-phenylacetamido}-2-methylpropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of benzyl 2-{[(3R)-3-benzyl-3-(2-nitrobenzenesulfonylamino)-2-oxo-azetidin-1-yl]-(R)-phenylacetamido}-2-methylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzyl 2-{[(3R)-3-benzyl-3-(2-nitrobenzenesulfonylamino)-2-oxo-azetidin-1-yl]-(R)-phenylacetamido}-2-methylpropanoate

There total 9 articles about benzyl 2-{[(3R)-3-benzyl-3-(2-nitrobenzenesulfonylamino)-2-oxo-azetidin-1-yl]-(R)-phenylacetamido}-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 923579-30-0
(3R)-3-benzyl-1-[(R)-phenyl-carboxymethyl]-3-(2-nitrobenzenesulfonylamino)-azetidin-2-one

: 55456-40-1
benzyl 2-aminoisobutyrate

: 923579-05-9
benzyl 2-{[(3R)-3-benzyl-3-(2-nitrobenzenesulfonylamino)-2-oxo-azetidin-1-yl]-(R)-phenylacetamido}-2-methylpropanoate

Guidance literature:: With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane; at -12 - 20 ℃;
DOI:10.1021/ol0626241

Reference yield:

: 923578-94-3
methyl (R)-2-amino-2-benzyl-3-hydroxypropanoate

: 923579-05-9
benzyl 2-{[(3R)-3-benzyl-3-(2-nitrobenzenesulfonylamino)-2-oxo-azetidin-1-yl]-(R)-phenylacetamido}-2-methylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / KHCO₃ / acetonitrile / 16 h / Heating

2: 46 percent / acetonitrile / 20 h / 20 °C

3: 93 percent / LiHMDS / tetrahydrofuran / 12 h / 0 °C

4: HF / acetonitrile; H₂O / 1 h / 0 - 20 °C

5: 0.012 g / Jones' reagent / acetone / 1 h / 20 °C

6: 55 percent / N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / CH₂Cl₂ / -12 - 20 °C

With jones' reagent; hydrogen fluoride; potassium hydrogencarbonate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water; acetone; acetonitrile;
DOI:10.1021/ol0626241

Reference yield:

: (2S,4R)-4-benzyl-2-(tert-butyl)-3-formyl-4-methoxycarbonyl-1,3-oxazolidine

: 923579-05-9
benzyl 2-{[(3R)-3-benzyl-3-(2-nitrobenzenesulfonylamino)-2-oxo-azetidin-1-yl]-(R)-phenylacetamido}-2-methylpropanoate

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / HCl / methanol; H₂O / 7 h / Heating

2: 89 percent / KHCO₃ / acetonitrile / 16 h / Heating

3: 46 percent / acetonitrile / 20 h / 20 °C

4: 93 percent / LiHMDS / tetrahydrofuran / 12 h / 0 °C

5: HF / acetonitrile; H₂O / 1 h / 0 - 20 °C

6: 0.012 g / Jones' reagent / acetone / 1 h / 20 °C

7: 55 percent / N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / CH₂Cl₂ / -12 - 20 °C

With hydrogenchloride; jones' reagent; hydrogen fluoride; potassium hydrogencarbonate; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; acetone; acetonitrile;
DOI:10.1021/ol0626241