55456-40-1

Basic information

• Product Name: H-Aib-OBzl
• Synonyms: H-Aib-OBzl;H-Aib-OBzl · HCl;2-AMino-2-Methylpropanoic acid benzyl;2-AMino-2-Methylpropanoic acid benzyl ester;alpha-Aminoisobutyric acid benzyl ester;benzyl 2-amino-2-methylpropanoate
• CAS NO: 55456-40-1
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.2423
• Mol File: 55456-40-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 131-131.5℃ (18 Torr)
• Appearance: /
• Density: 1.079±0.06 g/cm3(Predicted)
• PKA: 7.93±0.25(Predicted)
• CAS DataBase Reference: H-Aib-OBzl(CAS DataBase Reference)
• NIST Chemistry Reference: H-Aib-OBzl(55456-40-1)
• EPA Substance Registry System: H-Aib-OBzl(55456-40-1)

Safety Data

• Hazardous Substances Data: 55456-40-1(Hazardous Substances Data)

Usage

General Description

H-Aib-OBzl is a chemical compound with the formula C18H23NO3. It is an amide derivative of alpha-aminoisobutyric acid (Aib) and benzyl alcohol. H-Aib-OBzl has an Aib residue linked to a benzyl group through an amide bond, resulting in a relatively stable and non-reactive molecule. It is commonly used as a building block in peptide synthesis and drug development due to its unique structure and stability. Additionally, H-Aib-OBzl has potential applications in the field of medicinal chemistry and pharmaceutical research due to its ability to mimic natural amino acids and contribute to the development of new drugs and therapies.

Upstream product

• 62-57-7 2-Aminoisobutyric acid 
• 100-51-6 benzyl alcohol 
• 100-44-7 benzyl chloride 
• 84758-57-6 tert-butoxycarbonylamino-2-methyl-propionic acid benzyl ester 
• 60421-20-7 benzyl 2-amino-2-methylpropionate hydrochloride 

Downstream Products

• 84758-57-6 tert-butoxycarbonylamino-2-methyl-propionic acid benzyl ester 
• 79118-35-7 Boc-L-Pro-Aib-OBzl 
• 79118-36-8 Boc-MeA-MeA-OBzl 
• 79118-23-3 Boc-Leu-Aib-OBzl 
• 203636-24-2 Fmoc-Val-Aib-OBn 
• 211372-14-4 Fmoc-Aib-Aib-OBzl 
• 254112-92-0 2-[2-(3-benzyl-3-tert-butoxycarbonylamino-2-oxo-azetidin-1-yl)-acetylamino]-2-methyl-propionic acid benzyl ester 
• 923579-05-9 benzyl 2-{[(3R)-3-benzyl-3-(2-nitrobenzenesulfonylamino)-2-oxo-azetidin-1-yl]-(R)-phenylacetamido}-2-methylpropanoate 
• 661481-47-6 3-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyloxy)-1-(3-benzoyloxypropyl)-4-[(4-{(1E)-3-[1-carboxy-1-(methyl)ethylcarbamoyl]prop-1-enyl}phenyl)methyl]-5-isopropyl-1H-pyrazole 
• 60421-20-7 benzyl 2-amino-2-methylpropionate hydrochloride 
• 1433554-88-1 C₃₀H₃₉N₅O₁₁ 
• 1433554-91-6 1-[2-(benzyloxycarbonyl)-2-propyl]-4-[3-(trimethylsilyl)prop-2-ynyl]-1H-1,3,3-triazole 
• 1433554-94-9 1-[2-(benzyloxycarbonyl)-2-propyl]-4-propargyl-1H-1,2,3-triazole 
• 1433555-00-0 1-[2-(benzyloxycarbonyl)-2-propyl]-1'-(2,3,4,6-tetra-O-acetyl-α-D-mannosyl)-4,4'-methylenebis(1H-1,2,3-triazole) 

Relevant articles and documents

N-Pyrrolidine-based α/β-peptides incorporating ABOC, a constrained bicyclic β-amino acid, for asymmetric aldol reaction catalysis

A series of N-pyrrolidine-based α,β-peptide catalysts incorporating a constrained 2-aminobicyclo[2.2.2]octane carboxylic acid (ABOC) residue were synthesized and evaluated in the asymmetric aldol reaction from acetone and some p-substituted benzaldehydes. Their catalytic properties were shown to be highly dependent on the amino acid sequences and on the absolute configuration of the ABOC residue that played a determinant role. Among the peptides tested, the heterochiral tripeptide H-Pro-(R)-ABOC-Asp-OCH3 13, that adopts a turn conformation in the solid state, proved to be the most efficient catalyst affording β-hydroxy ketones in high yields and good enantioselectivities (up to 87%).

Cyclopropanecarboxylic acid esters as potential prodrugs with enhanced hydrolytic stability

Esters of cyclopropanecarboxylic acid demonstrate a substantial increase in stability under both acid- and base-catalyzed hydrolytic conditions. Comparison of the stability of valacyclovir 13 with the cyclopropane analogue 14 shows that at 40 °C and pH 6 the half-life of 14 is >300 h while the value for 13 is 69.7 h. CBS-QB3 calculations on isodesmic reactions for transfer of groups from an alkane to an ester show that a cyclopropyl group provides hyperconjugative stabilization.

PYRAZOLE DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, MEDICINAL USE THEREOF, AND INTERMEDIATE FOR PRODUCTION THEREOF

The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl group etc.; one of Q and T represents a group represented by the general formula: or a group represented by the general formula: while the other represents an optionally substituted C1-6 alkyl group etc.; R2 represents H, a halogen atom, OH, an optionally substituted C1-6 alkyl group etc.; X represents a single bond, O or S; Y represents a single bond, a C1-6 alkylene group etc. ; Z represents CO or SO2; R4 and R5 represent H, an optionally substituted C1-6 alkyl group etc.; and R3, R6 and R7 represent H, a halogen atom etc., pharmaceutically acceptable salts thereof or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT1 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutical compositions comprising the same, pharmaceutical uses thereof, and intermediates for production thereof.