Chemical Property of Lomeguatrib
Chemical Property:
- Vapor Pressure:1.5E-18mmHg at 25°C
- Refractive Index:1.797
- Boiling Point:683.8 °C at 760 mmHg
- PKA:9.42±0.10(Predicted)
- Flash Point:367.3 °C
- PSA：117.95000
- Density:2.07 g/cm3
- LogP:2.91930
- Storage Temp.:room temp
- Solubility.:DMSO: soluble10mg/mL, clear
- XLogP3:2
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:3
- Exact Mass:324.96329
- Heavy Atom Count:18
- Complexity:299
- Purity/Quality:
-
99%, *data from raw suppliers
Lomeguatrib *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
22
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=C(SC=C1Br)COC2=NC(=NC3=C2NC=N3)N
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Description
Lomeguatrib (192441-08-0) is a potent (IC50?= 9 nM) inhibitor of O6-Methylguanine-DNA Methyltransferase (MGMT), an important DNA repair protein.1?It is currently being investigated in cancers that have acquired resistant to the chemotherapeutic temozolomide2-5, as well as other chemotherapeutics6,7.
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Uses
O6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein which removes an alkyl group from the O6 position on guanine in an autoinactivating reaction. Although important in normal DNA repair, this reaction confers resistance to treatments that use O6-alkylating agents to produce cytotoxicity, e.g., in cancer. Lomeguatrib is a modified quanine base which acts as a pseudosubstrate inactivator of MGMT (IC50 = ~3 nM). A non-toxic compound, lomeguatrib completely inactivates MGMT in human prostate and colorectal tumors when given as a single 120 mg oral dose and in primary central nervous system cancers at 160 mg. Lomeguatrib is an inhibitor of O6-methylguanine-DNA methyltransferase (MGMT). Lomeguatrib attenuates MGMT activity in vitro and in vivo. Lomeguatrib enhances the antitumor activity of temozolomide in both human melanoma and MCF-7 xenografts.
