DNA Methyltransferase Inhibitors
DNA methyltransferase inhibitors are a class of compounds that target enzymes responsible for adding methyl groups to cytosine residues within DNA, known as DNA methyltransferases (DNMTs). These enzymes play a critical role in regulating gene expression by modifying DNA methylation patterns, which can affect chromatin structure and transcriptional activity. Aberrant DNA methylation patterns, such as hypermethylation of tumor suppressor genes or hypomethylation of oncogenes, are commonly observed in various diseases, including cancer and neurological disorders. By inhibiting DNMT activity, these inhibitors aim to alter DNA methylation profiles, potentially reversing abnormal gene silencing or activation associated with disease progression.
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