(R)-tert-butyl 3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidine-1-carboxylate
CAS No.:1422827-96-0
Molecular Formula:C₁₄H₁₉IN₆O₂
Molecular Weight:430.248
Hs Code.:

Synonyms:(R)-tert-butyl 3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidine-1-carboxylate

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Chemical Property of (R)-tert-butyl 3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidine-1-carboxylate

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Technology Process of (R)-tert-butyl 3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidine-1-carboxylate

There total 1 articles about (R)-tert-butyl 3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5399-92-8
4-chloro-1H-pyrazolo[3,4-d]pyrimidine

: 1422827-96-0
(R)-tert-butyl 3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium hydroxide / isopropyl alcohol / 95 °C

2: N-iodo-succinimide / N,N-dimethyl-formamide / 55 °C

3: di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 0 - 60 °C

With ammonium hydroxide; N-iodo-succinimide; di-isopropyl azodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield: 96.6%

: 13630-91-6
N-propargyl benzenesulfonamide

: 1422827-96-0
(R)-tert-butyl 3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidine-1-carboxylate

: (R)-tert-butyl 3-(4-amino-3-(3-(phenylsulfonamido)prop-1-yn-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidine-1-carboxylate

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 15h; Inert atmosphere;

Reference yield: 66.0%

: (3-fluoro-4-phenoxyphenyl)boronic acid

: 1422827-96-0
(R)-tert-butyl 3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidine-1-carboxylate

: (3R)-1-Boc-3-(4-amino-3-(3-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)tetrahydropyrrole

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; water; at 80 ℃; Inert atmosphere;