(E)-1-(R)-3-(4-amino-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidin-1-yl-4-(dimethylamino)but-2-en-1-one

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Chemical Name:(E)-1-(R)-3-(4-amino-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidin-1-yl-4-(dimethylamino)but-2-en-1-one
CAS No.:1422827-00-6
Molecular Formula:C₂₁H₂₄ClN₇O
Molecular Weight:425.921
Hs Code.:

Synonyms:(E)-1-(R)-3-(4-amino-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidin-1-yl-4-(dimethylamino)but-2-en-1-one

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Chemical Property of (E)-1-(R)-3-(4-amino-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidin-1-yl-4-(dimethylamino)but-2-en-1-one

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Technology Process of (E)-1-(R)-3-(4-amino-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidin-1-yl-4-(dimethylamino)but-2-en-1-one

There total 4 articles about (E)-1-(R)-3-(4-amino-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidin-1-yl-4-(dimethylamino)but-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1422827-98-2
(R,E)-1-(3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidin-1-yl)-4-(dimethylamino)but-2-en-1-one

: 1679-18-1
4-Chlorophenylboronic acid

: 1422827-00-6
(E)-1-(R)-3-(4-amino-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidin-1-yl-4-(dimethylamino)but-2-en-1-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,2-dimethoxyethane; water; at 100 ℃; for 12h; Inert atmosphere;

Reference yield:

: 1422827-96-0
(R)-tert-butyl 3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidine-1-carboxylate

: 1422827-00-6
(E)-1-(R)-3-(4-amino-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidin-1-yl-4-(dimethylamino)but-2-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / methanol; water / 2 h / 20 °C

2: triethylamine; HATU / N,N-dimethyl-formamide / 10 h / 70 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane; water / 12 h / 100 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; triethylamine; HATU; In methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 3: |Suzuki Coupling;

Reference yield:

: 1422827-97-1
(R)-3-iodo-1-(pyrrolidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

: 1422827-00-6
(E)-1-(R)-3-(4-amino-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pyrrolidin-1-yl-4-(dimethylamino)but-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; HATU / N,N-dimethyl-formamide / 10 h / 70 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / 1,2-dimethoxyethane; water / 12 h / 100 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; triethylamine; HATU; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;