2-(4-Chloro-phenyl)-5-(2,2-dimethyl-4-morpholin-4-yl-4-oxo-butyl)-4-thioxo-4,5-dihydro-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-6-one

Base Information

Chemical Name:2-(4-Chloro-phenyl)-5-(2,2-dimethyl-4-morpholin-4-yl-4-oxo-butyl)-4-thioxo-4,5-dihydro-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-6-one
CAS No.:898552-48-2
Molecular Formula:C₂₄H₂₄ClN₃O₄S
Molecular Weight:485.991
Hs Code.:

Synonyms:2-(4-Chloro-phenyl)-5-(2,2-dimethyl-4-morpholin-4-yl-4-oxo-butyl)-4-thioxo-4,5-dihydro-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-6-one

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Chemical Property of 2-(4-Chloro-phenyl)-5-(2,2-dimethyl-4-morpholin-4-yl-4-oxo-butyl)-4-thioxo-4,5-dihydro-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-6-one

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Technology Process of 2-(4-Chloro-phenyl)-5-(2,2-dimethyl-4-morpholin-4-yl-4-oxo-butyl)-4-thioxo-4,5-dihydro-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-6-one

There total 9 articles about 2-(4-Chloro-phenyl)-5-(2,2-dimethyl-4-morpholin-4-yl-4-oxo-butyl)-4-thioxo-4,5-dihydro-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 898552-43-7
4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyric acid 4-oxo-4H-benzo[d][1,2,3]triazin-3-yl ester

: 898552-48-2
2-(4-Chloro-phenyl)-5-(2,2-dimethyl-4-morpholin-4-yl-4-oxo-butyl)-4-thioxo-4,5-dihydro-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-6-one

Guidance literature:: In chloroform; for 1h;

Reference yield:

: 898552-72-2
ethyl 3,3-dimethyl-4-aminobutanoate hydrochloride

: 898552-48-2
2-(4-Chloro-phenyl)-5-(2,2-dimethyl-4-morpholin-4-yl-4-oxo-butyl)-4-thioxo-4,5-dihydro-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-6-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / chloroform; water / pH 7.1 - 7.4

2: potassium carbonate / 6 h / 120 °C

3: trifluoroacetic acid / water / 16 h / 90 °C

4: dmap; triethylamine / dichloromethane / 16 h / 25 °C

5: chloroform / 1 h

With dmap; sodium hydrogencarbonate; potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; chloroform; water;

Reference yield:

: 130912-54-8
3,3-dimethyl-4-nitro-butyric acid ethyl ester

: 898552-48-2
2-(4-Chloro-phenyl)-5-(2,2-dimethyl-4-morpholin-4-yl-4-oxo-butyl)-4-thioxo-4,5-dihydro-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-6-one

Guidance literature:: Multi-step reaction with 8 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 110 °C / 3344.22 Torr

2: hydrogenchloride; water / 20 h / 120 °C

3: ethanol / 16 h / 85 °C / Heating / reflux

4: sodium hydrogencarbonate / chloroform; water / pH 7.1 - 7.4

5: potassium carbonate / 6 h / 120 °C

6: trifluoroacetic acid / water / 16 h / 90 °C

7: dmap; triethylamine / dichloromethane / 16 h / 25 °C

8: chloroform / 1 h

With hydrogenchloride; dmap; water; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; chloroform; water;