4-aMino-3,3-diMethyl-butyric acid ethyl ester hydrochloride

Base Information

• Chemical Name: 4-aMino-3,3-diMethyl-butyric acid ethyl ester hydrochloride
• CAS No.: 898552-72-2
• Molecular Formula: C₈H₁₇NO₂*ClH
• Molecular Weight: 195.689
• Mol file: 898552-72-2.mol

Synonyms:ethyl 3,3-dimethyl-4-aminobutanoate hydrochloride

Chemical Property of 4-aMino-3,3-diMethyl-butyric acid ethyl ester hydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Ethyl4-Amino-3,3-dimethylbutanoateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-aMino-3,3-diMethyl-butyric acid ethyl ester hydrochloride

There total 6 articles about 4-aMino-3,3-diMethyl-butyric acid ethyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

acetyl chloride (75-36-5) + 4-amino-3,3-dimethylbutanoic acid hydrochloride → ethyl 3,3-dimethyl-4-aminobutanoate hydrochloride (898552-72-2)

Guidance literature:

In ethanol; at 85 ℃; for 16h; Heating / reflux;

Reference yield: 52.7%

3,3-dimethyl-4-nitro-butyric acid ethyl ester (130912-54-8) → ethyl 3,3-dimethyl-4-aminobutanoate hydrochloride (898552-72-2)

Guidance literature:

3,3-dimethyl-4-nitro-butyric acid ethyl ester; With 5%-palladium/activated carbon; hydrogen; acetic acid; In ethanol; at 70 ℃; for 5h; under 3750.38 Torr;

With di-tert-butyl dicarbonate; at 20 ℃; for 20h;

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 24h;

Reference yield:

ethyl 4-(tert-butoxycarbonylamino)-3,3-dimethylbutanoate → ethyl 3,3-dimethyl-4-aminobutanoate hydrochloride (898552-72-2)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 24h;

upstream raw materials:

acetyl chloride

4-amino-3,3-dimethylbutanoic acid ethyl ester

ethyl 3-methylbut-2-enoate

3,3-dimethyl-4-nitro-butyric acid ethyl ester

Downstream raw materials:

4-[((tert-butoxy)carbonyl)amino]-3,3-dimethylbutanoic acid

4-[2-(4-chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyric acid

4-[2-(4-Chloro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-3,3-dimethyl-butyric acid ethyl ester

3,3-Dimethyl-4-[2-(4-nitro-phenyl)-6-oxo-4-thioxo-6H-1-oxa-3b,5-diaza-cyclopenta[a]pentalen-5-yl]-butyric acid

Refernces

• 1、 -. "AMINOPYRAZOLONE DERIVATIVE". . . Retrieved 2017/01/05.
• 2、 -. "Rigidified Compounds for Modulating Heparanase Activity". Page/Page column 44. . Retrieved 2010/11/30.