3-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-propionic acid methyl ester

Base Information

• Chemical Name: 3-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-propionic acid methyl ester
• CAS No.: 199273-20-6
• Molecular Formula: C₄₈H₄₈N₂O₃S₂
• Molecular Weight: 765.053
• Mol file: 199273-20-6.mol

Synonyms:3-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-propionic acid methyl ester

Chemical Property of 3-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-propionic acid methyl ester

There total 1 articles about 3-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

Methyl 3-bromopropionate (3395-91-3) + N-[2-[(triphenylmethyl)thio]ethyl]-2-[[2-[(triphenylmethyl)thio]ethyl]amino]acetamide (152863-83-7) → 3-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-propionic acid methyl ester (199273-20-6)

Guidance literature:

With potassium carbonate; potassium hydrogencarbonate; In acetonitrile; at 80 ℃; for 12h;

DOI:10.1021/jm990103w

Reference yield:

3-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-propionic acid methyl ester (199273-20-6) → 3-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-propionic acid

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; for 3h; Ambient temperature;

DOI:10.1021/jm990103w

Reference yield:

3-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-propionic acid methyl ester (199273-20-6) → 3-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 3.0 g / aq. LiOH / methanol; tetrahydrofuran / 3 h / Ambient temperature

2: 1,3-dicyclohexylcarbodiimide / tetrahydrofuran / 2 h / Ambient temperature

With lithium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol;

DOI:10.1021/jm990103w

upstream raw materials:

Methyl 3-bromopropionate

N-[2-[(triphenylmethyl)thio]ethyl]-2-[[2-[(triphenylmethyl)thio]ethyl]amino]acetamide

Downstream raw materials:

N-(4,4'-diamino-biphenyl-2-ylmethyl)-3-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-propionamide