152863-83-7

Upstream product

• 136721-64-7 N-(2-bromoacetyl)-S-(triphenylmethyl)-2-aminoethanethiol 
• 1095-85-8 2-amino tritylthio ethane 
• 258826-31-2 N-[2-((triphenylmethyl)thio)ethyl]-chloroacetamide 
• 76-83-5 trityl chloride 
• 76-84-6 triphenylmethyl alcohol 
• 598-21-0 2-Bromoacetyl bromide 
• 15297-43-5 <2-<(triphenylmethyl)thio>ethyl>amine hydrochloride 

Downstream Products

• 258826-33-4 heptanoic acid (2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amide 
• 915380-02-8 4-{(2-tritylsulfanyl-ethyl)-[(2-tritylsulfanyl-ethylcarbamoyl)-methyl]-amino}-butyric acid methyl ester 
• 189818-57-3 N-[[[[2-[(triphenylmethyl)thio]ethyl]amino]carbonyl]-methyl]-N-(3′-chloropropyl)-S-(triphenylmethyl)-2-aminoethanethiol 
• 228253-42-7 3,6-diaza-5-oxo-3-[2-((triphenylmethyl)thio)ethyl]-8-[(triphenylmethyl)thio]octanoic acid 
• 1240609-20-4 C₆₃H₆₁N₃O₃S₂ 
• 1539311-26-6 trimethyl-γ-L-glutamyl-L-glutamyl-7,10-diaza-9-oxo-7-[2-(triphenylmethyl)thioethyl]-12-[(triphenylmethyl)-thio]dodecanamide 
• 228253-37-0 methyl 7,10-diaza-9-oxo-7-[2-((triphenylmethyl)thio)-ethyl]-12-[(triphenylmethyl)thio]dodecanoate 
• 1444512-56-4 2-((5-(4-((1E,4E)-5-(4-(dimethylamino)phenyl)-3-oxopenta-1,4-dienyl)phenoxy)pentyl)(2-(tritylthio)ethyl)amino)-N-(2-(tritylthio)ethyl)acetamide 
• 1444512-49-5 2-((3-(4-((1E,4E)-5-(4-(dimethylamino)phenyl)-3-oxopenta-1,4-dienyl)phenoxy)propyl)(2-(tritylthio)ethyl)amino)-N-(2-(tritylthio)ethyl)acetamide 
• 1353721-33-1 (6-[3',6'-diaza-5'-oxo-3'-(2-triphenylmethylthioethyl)-8'-triphenylmethylthio]octanamidohexyl β-N-acetylgalactoseamine per-o-acetate) 
• 1353721-35-3 (6-[3',6'-diaza-5'-oxo-3'-(2-triphenylmethyl thioethyl)-8'-triphenylmethylthio]octanamidohexyl β-N-acetylgalactosamine) 
• 681486-02-2 N-2-((triphenylmethyl)thio)ethyll-3-aza-18-ethyloxycarbonyl-3-[2-((triphenylmethyl)thio)ethyl]octadecanamide 
• 459839-45-3 N-[2-((triphenylmethyl)thio)ethyl]-3-aza-3-[2-((triphenylmethyl)thio)ethyl]heptadecanamide 
• 1159301-70-8 C₆₂H₆₀N₄O₂S₃ 

Relevant academic research and scientific papers

COMPOUND FOR BONE SCANNING AND USE THEREOF

The disclosure provides a compound comprising bisphosphonate functional group and chelating agent. The bisphosphonate functional group part has high affinity for bone tissue, and the chelating agent part has high affinity for metal tracer such as radioisotope. The disclosed compound could be rapidly adsorbed onto the bone surface, and could steady emit ionizing radiation. Therefore, the disclosed compound is suitable for bone scanning technology to find abnormalities in bone.

Bifunctional compound and method for manufacturing the same

A bifunctional compound and a method for manufacturing the same are revealed. The structural formula of the compound includes two main functional groups. One functional group is a diamide dithiolate (N2S2) ligand able to bind with radioisotopes. The other functional group is polybasic carboxylic acid that binds to biochemical substances. Based on properties of the above two functional groups, the compound of the present invention can be used for preparation of radiopharmaceuticals such as radiotracter for disease diagnosis or radioactive therapeutic agent for disease treatment.

PRECURSOR USED FOR LABELING HEPATORCYTE RECEPTOR AND CONTAINING TRISACCHARIDE AND DIAMIDE DEMERCAPTIDE LIGAND, METHOD FOR PREPARING THE SAME, RADIOTRACER AND PHARMACEUTICAL COMPOSITION OF THE SAME

A precursor used for labeling hepatocyte receptors and applied to radiotracers for imaging or pharmaceutical compositions for liver cancers is revealed. The precursor is a bifunctional compound. The bifunctional group includes a trisaccharide structure an

BIFUNCTIONAL COMPOUND WITH MONOSACCHARIDE AND N2S2 LIGAND, AND PREPARATION AND USE THEREOF

A bifunctional compound with a monosaccharide and a N2S2 ligand, and more particularly, a bifunctional compound with a N2S2 ligand and aminohexylacetyl galactosamine (ah-GalNAc4) is provided. A method for preparing the bifunctional compound with a monosaccharide and a N2S2 ligand is also provided, including activating a carboxyl group in an organic ligand, reacting the activated carboxyl group with a galactopyranoside through amidation, and then hydrolyzing. The bifunctional compound of the present invention is widely useful in nuclear medicine for preparation of liver imaging agents for assisting in correct diagnosis of diseases.

H3LMN COMPOUND USED AS RADIOACTIVE AGENT FOR TREATMENT OF LIVER CANCER AND MANUFACTURING METHOD THEREOF

H3LMN series compounds used as radioactive agents for treatment of liver cancer and a manufacturing method thereof are revealed. 2-thioethylamine hydrochloride is reacted with triphenylmethanol for protection of thiol to obtain 2-[(triphenylmet

Compound containing carboxylate ester and N2S2 ligand bi-functional groups and manufacturing method thereof

A compound containing carboxylate ester and N2S2 ligand bi-functional groups and a manufacturing method thereof are disclosed. The S in the N2S2 ligand of the compound containing carboxylate ester and N2S2 ligand bi-functional groups includes a protective

Compound containing carboxylate ester and N2S2 ligand bi-functional groups and manufacturing method thereof

A compound containing carboxylate ester and N2S2 ligand bi-functional groups and a manufacturing method thereof are disclosed. The S in the N2S2 ligand of the compound containing carboxylate ester and N2S2 ligand bi-functional groups includes a protective

Bisamidate and mixed amine/amidate NiN2S2 complexes as models for nickel-containing acetyl coenzyme A synthase and superoxide dismutase: An experimental and computational study

The distal nickel site of acetyl-CoA synthase (Nid-ACS) and reduced nickel superoxide dismutase (Ni-SOD) display similar square-planar NiIIN2S2 coordination environments. One difference between these two sites,

Tc-labeled arylpiperazine derivatives for imaging serotonin receptor

The present invention relates to Tc-labeled arylpiperazine derivatives for imaging serotonin receptor and, more particularly, to arylpiperazine derivatives coupled with MAMA-disulfide, N2S2 or dimethyl-N2S2 chel

Synthesis and biological evaluation of technetium-99m-labeled deoxyglucose derivatives as imaging agents for tumor

Three deoxyglucose (DG) derivatives, S-DG, MAG3-DG and MAMA-BA-DG, were synthesized and labeled successfully with high labeling yields and high radio-chemical purities. Biodistribution in tumor-bearing mice demonstrated that these three new su