N-{(S)-1-[3-(2-Amino-acetylamino)-phenyl]-2-pyrrolidin-1-yl-ethyl}-2-(3,4-dichloro-phenyl)-N-methyl-acetamide

Base Information

• Chemical Name: N-{(S)-1-[3-(2-Amino-acetylamino)-phenyl]-2-pyrrolidin-1-yl-ethyl}-2-(3,4-dichloro-phenyl)-N-methyl-acetamide
• CAS No.: 778641-24-0
• Molecular Formula: C₂₃H₂₈Cl₂N₄O₂
• Molecular Weight: 463.407
• Mol file: 778641-24-0.mol

Synonyms:N-{(S)-1-[3-(2-Amino-acetylamino)-phenyl]-2-pyrrolidin-1-yl-ethyl}-2-(3,4-dichloro-phenyl)-N-methyl-acetamide

Chemical Property of N-{(S)-1-[3-(2-Amino-acetylamino)-phenyl]-2-pyrrolidin-1-yl-ethyl}-2-(3,4-dichloro-phenyl)-N-methyl-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-{(S)-1-[3-(2-Amino-acetylamino)-phenyl]-2-pyrrolidin-1-yl-ethyl}-2-(3,4-dichloro-phenyl)-N-methyl-acetamide

There total 1 articles about N-{(S)-1-[3-(2-Amino-acetylamino)-phenyl]-2-pyrrolidin-1-yl-ethyl}-2-(3,4-dichloro-phenyl)-N-methyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{[3-((S)-1-{[2-(3,4-Dichloro-phenyl)-acetyl]-methyl-amino}-2-pyrrolidin-1-yl-ethyl)-phenylcarbamoyl]-methyl}-carbamic acid benzyl ester; hydrochloride → N-{(S)-1-[3-(2-Amino-acetylamino)-phenyl]-2-pyrrolidin-1-yl-ethyl}-2-(3,4-dichloro-phenyl)-N-methyl-acetamide (778641-24-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 65h; under 517.1 Torr;

DOI:10.1021/jm950813b

Reference yield: 34.0%

N-{(S)-1-[3-(2-Amino-acetylamino)-phenyl]-2-pyrrolidin-1-yl-ethyl}-2-(3,4-dichloro-phenyl)-N-methyl-acetamide (778641-24-0) + N-methylaminocarbonylmethylsuccinamic acid → KA 12

Guidance literature:

N-methylaminocarbonylmethylsuccinamic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

N-{(S)-1-[3-(2-Amino-acetylamino)-phenyl]-2-pyrrolidin-1-yl-ethyl}-2-(3,4-dichloro-phenyl)-N-methyl-acetamide; In N,N-dimethyl-formamide; at 50 ℃; for 18h;

DOI:10.1021/jm034234f

Reference yield:

C15H21N3O8S (1256269-52-9) + N-{(S)-1-[3-(2-Amino-acetylamino)-phenyl]-2-pyrrolidin-1-yl-ethyl}-2-(3,4-dichloro-phenyl)-N-methyl-acetamide (778641-24-0) → C36H44Cl2N6O8S

Guidance literature:

C₁₅H₂₁N₃O₈S; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h; Inert atmosphere;

N-{(S)-1-[3-(2-Amino-acetylamino)-phenyl]-2-pyrrolidin-1-yl-ethyl}-2-(3,4-dichloro-phenyl)-N-methyl-acetamide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 26h; Inert atmosphere;

DOI:10.1021/ml1001294

Downstream raw materials:

(S)-2-(3,4-dichlorophenyl)-N-methyl-N-(1-(3-(2-(2-(4-(methylamino)butylamino)-2-oxoethoxy)acetamido)phenyl)-2-(pyrrolidin-1-yl)ethyl)acetamide