(S)-2-(3,4-dichlorophenyl)-N-methyl-N-(1-(3-(2-(2-(4-(methylamino)butylamino)-2-oxoethoxy)acetamido)phenyl)-2-(pyrrolidin-1-yl)ethyl)acetamide

Base Information

• Chemical Name: (S)-2-(3,4-dichlorophenyl)-N-methyl-N-(1-(3-(2-(2-(4-(methylamino)butylamino)-2-oxoethoxy)acetamido)phenyl)-2-(pyrrolidin-1-yl)ethyl)acetamide
• CAS No.: 1256269-44-9
• Molecular Formula: C₃₀H₄₁Cl₂N₅O₄
• Molecular Weight: 606.593
• Mol file: 1256269-44-9.mol

Synonyms:

Chemical Property of (S)-2-(3,4-dichlorophenyl)-N-methyl-N-(1-(3-(2-(2-(4-(methylamino)butylamino)-2-oxoethoxy)acetamido)phenyl)-2-(pyrrolidin-1-yl)ethyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(3,4-dichlorophenyl)-N-methyl-N-(1-(3-(2-(2-(4-(methylamino)butylamino)-2-oxoethoxy)acetamido)phenyl)-2-(pyrrolidin-1-yl)ethyl)acetamide

There total 2 articles about (S)-2-(3,4-dichlorophenyl)-N-methyl-N-(1-(3-(2-(2-(4-(methylamino)butylamino)-2-oxoethoxy)acetamido)phenyl)-2-(pyrrolidin-1-yl)ethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C36H44Cl2N6O8S → (S)-2-(3,4-dichlorophenyl)-N-methyl-N-(1-(3-(2-(2-(4-(methylamino)butylamino)-2-oxoethoxy)acetamido)phenyl)-2-(pyrrolidin-1-yl)ethyl)acetamide (1256269-44-9)

Guidance literature:

With potassium carbonate; thiophenol; In tetrahydrofuran; at 20 ℃; for 8h; Inert atmosphere;

DOI:10.1021/ml1001294

Reference yield:

C15H21N3O8S (1256269-52-9) + N-{(S)-1-[3-(2-Amino-acetylamino)-phenyl]-2-pyrrolidin-1-yl-ethyl}-2-(3,4-dichloro-phenyl)-N-methyl-acetamide (778641-24-0) → (S)-2-(3,4-dichlorophenyl)-N-methyl-N-(1-(3-(2-(2-(4-(methylamino)butylamino)-2-oxoethoxy)acetamido)phenyl)-2-(pyrrolidin-1-yl)ethyl)acetamide (1256269-44-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere

1.2: 26 h / 0 - 20 °C / Inert atmosphere

2.1: potassium carbonate; thiophenol / tetrahydrofuran / 8 h / 20 °C / Inert atmosphere

With potassium carbonate; benzotriazol-1-ol; thiophenol; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ml1001294

upstream raw materials:

C₁₅H₂₁N₃O₈S

N-{(S)-1-[3-(2-Amino-acetylamino)-phenyl]-2-pyrrolidin-1-yl-ethyl}-2-(3,4-dichloro-phenyl)-N-methyl-acetamide