Technology Process of 6-bromo-3-(3-bromo-4-hydroxybenzyl)-4-(hydroxymethyl)benzene-1,2-diol
There total 10 articles about 6-bromo-3-(3-bromo-4-hydroxybenzyl)-4-(hydroxymethyl)benzene-1,2-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-bromo-4-(3-bromo-4-methoxybenzyl)-2,3-dimethoxy-5-(methoxymethyl)benzene;
With
boron tribromide;
In
dichloromethane;
at 0 - 20 ℃;
In
tetrahydrofuran; water;
for 1h;
DOI:10.1021/acs.joc.7b02028
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium acetate; bromine / acetic acid / 12 h / 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h
3.1: toluene-4-sulfonic acid hydrazide; potassium carbonate / 1,4-dioxane / 4 h / 110 °C
4.1: boron tribromide / dichloromethane / 0 - 20 °C
4.2: 1 h
With
bromine; sodium acetate; boron tribromide; potassium carbonate; toluene-4-sulfonic acid hydrazide;
In
1,4-dioxane; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/acs.joc.7b02028
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: diethyl ether / Molecular sieve
2.1: bromine / dichloromethane
3.1: boron trichloride / dichloromethane
4.1: toluene-4-sulfonic acid hydrazide; potassium carbonate / 1,4-dioxane / 4 h / 110 °C
5.1: boron tribromide / dichloromethane / 0 - 20 °C
5.2: 1 h
With
bromine; boron trichloride; boron tribromide; potassium carbonate; toluene-4-sulfonic acid hydrazide;
In
1,4-dioxane; diethyl ether; dichloromethane;
DOI:10.1021/acs.joc.7b02028
