2S,4'R,8'R-α-tocopheryl acetate

Base Information

• Chemical Name: 2S,4'R,8'R-α-tocopheryl acetate
• CAS No.: 54165-54-7
• Molecular Formula: C₃₁H₅₂O₃
• Molecular Weight: 472.752
• Mol file: 54165-54-7.mol

Synonyms:2S,4'R,8'R-α-tocopheryl acetate

Chemical Property of 2S,4'R,8'R-α-tocopheryl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2S,4'R,8'R-α-tocopheryl acetate

There total 32 articles about 2S,4'R,8'R-α-tocopheryl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E,Z)-(all-rac)-3-phytyl-2,5,6-trimethylhydroquinone-1-acetate (728894-66-4) → vitamin E acetate (58-95-7,7695-91-2,18920-61-1,52225-20-4,54165-54-7,66900-46-7,79200-45-6,79200-46-7,79200-47-8,79434-84-7,79434-85-8,79434-86-9,79434-87-0,79434-88-1,104154-81-6,1406-70-8,54-22-8)

Guidance literature:

With trifluorormethanesulfonic acid; In 4-butanolide; at 100 ℃; for 1h;

Reference yield: 99.21%

vitamin E (59-02-9,18920-62-2) + acetic anhydride (108-24-7) → vitamin E acetate (58-95-7,7695-91-2,18920-61-1,52225-20-4,54165-54-7,66900-46-7,79200-45-6,79200-46-7,79200-47-8,79434-84-7,79434-85-8,79434-86-9,79434-87-0,79434-88-1,104154-81-6,1406-70-8,54-22-8)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; at 100 ℃; for 1h; Reagent/catalyst; Temperature; Concentration;

Reference yield: 94.94%

isophytol (505-32-8) + 2,3,5-trimethyl-1,4-hydroquinone diacetate (7479-28-9) → vitamin E acetate (58-95-7,7695-91-2,18920-61-1,52225-20-4,54165-54-7,66900-46-7,79200-45-6,79200-46-7,79200-47-8,79434-84-7,79434-85-8,79434-86-9,79434-87-0,79434-88-1,104154-81-6,1406-70-8,54-22-8)

Guidance literature:

With hydrogenchloride; aluminum (III) chloride; In water; ethyl acetate; at 60 ℃; for 6h; Temperature; Reagent/catalyst; Time;

upstream raw materials:

3,5,6-trimethyl-2-phytylhydroquinone

acetic anhydride

vitamin E

α-tocotrienol

Downstream raw materials:

vitamin E

acetic acid

N-(phenylmethyl)acetamide

Duroquinone