1-({5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl}carbamoyl)cyclopropane-1-carboxylic acid

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Chemical Name:1-({5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl}carbamoyl)cyclopropane-1-carboxylic acid
CAS No.:1223403-86-8
Molecular Formula:C₂₁H₁₉F₂N₅O₃
Molecular Weight:427.41
Hs Code.:

Synonyms:1-({5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl}carbamoyl)cyclopropane-1-carboxylic acid

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Chemical Property of 1-({5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl}carbamoyl)cyclopropane-1-carboxylic acid

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Technology Process of 1-({5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl}carbamoyl)cyclopropane-1-carboxylic acid

There total 2 articles about 1-({5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl}carbamoyl)cyclopropane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1223403-85-7
(R)-methyl 1-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-ylcarbamoyl)cyclopropanecarboxylate

: 1223403-86-8
1-({5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl}carbamoyl)cyclopropane-1-carboxylic acid

Guidance literature:: (R)-methyl 1-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-ylcarbamoyl)cyclopropanecarboxylate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 5h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=~ 3;

Reference yield: 71.0%

: 598-10-7
cyclopropane-1,1-dicarboxylic acid

: 1223404-88-3
5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-amine

: 1223403-86-8
1-({5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl}carbamoyl)cyclopropane-1-carboxylic acid

Guidance literature:: cyclopropane-1,1-dicarboxylic acid; With thionyl chloride; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-amine; In tetrahydrofuran; at 10 - 15 ℃; for 10h; Inert atmosphere;

Reference yield: 58.0%

: 1223403-86-8
1-({5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl}carbamoyl)cyclopropane-1-carboxylic acid

: 122536-94-1,111810-68-5
(S)-3-hydroxypyrrolidine hydrochloride

: N-{5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl}-1-[(3S)-3-hydroxypyrrolidine-1-carbonyl]cyclopropane-1-carboxamide

Guidance literature:: 1-({5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl}carbamoyl)cyclopropane-1-carboxylic acid; With oxalyl dichloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 15 ℃; for 4h; Cooling with ice;

(S)-3-hydroxypyrrolidine hydrochloride; With potassium carbonate; In tetrahydrofuran; water; at 20 ℃; for 10h;