(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine

Base Information

Chemical Name:(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine
CAS No.:1223404-88-3
Molecular Formula:C₁₆H₁₅F₂N₅
Molecular Weight:315.325
Hs Code.:
Mol file:1223404-88-3.mol

Synonyms:5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-amine

Suppliers and Price of (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
(R)-5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine 95%+
1g
$ 1350.00

Ambeed
(R)-5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine 97%
5g
$ 402.00

Ambeed
(R)-5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine 97%
1g
$ 111.00

Ambeed
(R)-5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine 97%
250mg
$ 44.00

AK Scientific
(R)-5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine
5g
$ 863.00

Total 36 raw suppliers

Chemical Property of (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine

Chemical Property:

PKA:3.14±0.30(Predicted)
Density:1.50±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

(R)-5-(2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine 95%+ ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine

There total 16 articles about (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1223404-90-7
(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine

: 1223404-88-3
5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-amine

Guidance literature:: With ammonium chloride; zinc; In methanol; dichloromethane; water; at 20 ℃;

Reference yield:

: 1363380-51-1
5-chloro-3-nitropyrazolo[1,5-a]pyrimidine

: 1223404-88-3
5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-amine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran; ethanol / 40 - 50 °C / Inert atmosphere

2: zinc; hydrogenchloride / tetrahydrofuran; water / 5 - 30 °C / Inert atmosphere

With hydrogenchloride; triethylamine; zinc; In tetrahydrofuran; ethanol; water;

Reference yield:

: 1218935-59-1,1217630-38-0
(R)-(+)-2-(2,5-difluorophenyl)pyrrolidine

: 1223404-88-3
5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-amine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 20 - 65 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran; ethanol / 40 - 50 °C / Inert atmosphere

3: zinc; hydrogenchloride / tetrahydrofuran; water / 5 - 30 °C / Inert atmosphere

With hydrogenchloride; triethylamine; zinc; In tetrahydrofuran; ethanol; water;