Technology Process of N-Benzyloxy-3-((3aS,4S,6R,7S,7aS)-4-benzyloxy-7-hydroxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yl)-propionamide
There total 12 articles about N-Benzyloxy-3-((3aS,4S,6R,7S,7aS)-4-benzyloxy-7-hydroxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yl)-propionamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dicyclohexyl-carbodiimide;
In
tetrahydrofuran;
for 20h;
Ambient temperature;
DOI:10.1246/bcsj.65.567
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 75 percent / pyridine / CH2Cl2 / 2 h / Ambient temperature
2: 94.3 percent / 2-naphthalenesulfonic acid / acetone / 8 h / Ambient temperature
3: 94 percent / triethylamine / tetrahydrofuran / Ambient temperature
4: 1.) Na / 1.) toluene, reflux, 2.) toluene, reflux, overnight
5: 70 percent / DMSO, NaCl / H2O / 15 h / 145 °C
6: 1 g / 1 M aq. KOH / methanol / Ambient temperature
7: 96 percent / diethyl ether
8: 95 percent / pyridinium chlorochromate (PCC) / CH2Cl2 / Ambient temperature
9: 97 percent / NaBH4 / ethanol / 0.5 h / Ambient temperature
10: 95 percent / 1 M NaOH / ethanol / 15 h / Ambient temperature
11: 85 percent / DCC / tetrahydrofuran / 20 h / Ambient temperature
With
pyridine; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; naphthalene-2-sulfonate; sodium; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; pyridinium chlorochromate; sodium chloride;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; acetone;
DOI:10.1246/bcsj.65.567
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 94.3 percent / 2-naphthalenesulfonic acid / acetone / 8 h / Ambient temperature
2: 94 percent / triethylamine / tetrahydrofuran / Ambient temperature
3: 1.) Na / 1.) toluene, reflux, 2.) toluene, reflux, overnight
4: 70 percent / DMSO, NaCl / H2O / 15 h / 145 °C
5: 1 g / 1 M aq. KOH / methanol / Ambient temperature
6: 96 percent / diethyl ether
7: 95 percent / pyridinium chlorochromate (PCC) / CH2Cl2 / Ambient temperature
8: 97 percent / NaBH4 / ethanol / 0.5 h / Ambient temperature
9: 95 percent / 1 M NaOH / ethanol / 15 h / Ambient temperature
10: 85 percent / DCC / tetrahydrofuran / 20 h / Ambient temperature
With
potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; naphthalene-2-sulfonate; sodium; dimethyl sulfoxide; triethylamine; dicyclohexyl-carbodiimide; pyridinium chlorochromate; sodium chloride;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; acetone;
DOI:10.1246/bcsj.65.567
