2-(2-chloro-5-fluoro-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclopentylmethyl-amide

Base Information

Chemical Name:2-(2-chloro-5-fluoro-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclopentylmethyl-amide
CAS No.:666263-11-2
Molecular Formula:C₁₈H₁₇ClF₄N₄O
Molecular Weight:416.806
Hs Code.:

Synonyms:2-(2-chloro-5-fluoro-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclopentylmethyl-amide

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Chemical Property of 2-(2-chloro-5-fluoro-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclopentylmethyl-amide

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Technology Process of 2-(2-chloro-5-fluoro-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclopentylmethyl-amide

There total 3 articles about 2-(2-chloro-5-fluoro-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclopentylmethyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 666262-40-4
2-chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid (cyclopentylmethyl)-amide

: 452-83-5
2-chloro-5-fluoroaniline

: 666263-11-2
2-(2-chloro-5-fluoro-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclopentylmethyl-amide

Guidance literature:: In 1,4-dioxane; at 100 ℃; for 18h;

Reference yield:

: 58714-85-5
cyclopropylmethyl-amine hydrochloride

: 666263-11-2
2-(2-chloro-5-fluoro-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclopentylmethyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / -2 - 0 °C

2: 1,4-dioxane / 18 h / 100 °C / Under nitrogen

With triethylamine; In 1,4-dioxane; dichloromethane;

Reference yield:

: 154934-99-3
2-chloro-4-(trifluoromethyl)pyrimidine-5-carbonyl chloride

: 666263-11-2
2-(2-chloro-5-fluoro-phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclopentylmethyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / -2 - 0 °C

2: 1,4-dioxane / 18 h / 100 °C / Under nitrogen

With triethylamine; In 1,4-dioxane; dichloromethane;