452-83-5

Basic information

• Product Name: 2-Chloro-5-fluoroaniline
• Synonyms: 5-FLUORO-2-CHLOROANILINE;2-CHLORO-5-FLUOROANILINE;2-CHLORO-5-FLUORO-PHENYLAMINE;2-Chloro-5-fluoroaniline 97%;2-Chloro-5-fluoroaniline97%;2-Chloro-5-fluorobenzeneamine;Chlorofluoroaniline 25---;Benzenamine, 2-chloro-5-fluoro-
• CAS NO: 452-83-5
• Molecular Formula: C₆H₅ClFN
• Molecular Weight: 145.56
• EINECS: 226-696-8
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Aniline;Anilines, Amides & Amines;Chlorine Compounds;Fluorine Compounds
• Mol File: 452-83-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 26°C
• Boiling Point: 211°C
• Flash Point: 211°C
• Appearance: /
• Density: 1.349 g/cm³
• Vapor Pressure: 0.0974mmHg at 25°C
• Refractive Index: 1.5560
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1?+-.0.10(Predicted)
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: 2-Chloro-5-fluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-fluoroaniline(452-83-5)
• EPA Substance Registry System: 2-Chloro-5-fluoroaniline(452-83-5)

Safety Data

• Hazard Codes: T,Xn
• Statements: 20/21/22-36/37/38-23/24/25-22-36/38-33
• Safety Statements: 26-36/37/39-45-36/37-28
• RIDADR: UN2811
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 452-83-5(Hazardous Substances Data)

Usage

Chemical Properties

Yellowish oily liquid or crystal

Uses

2-Chloro-5-fluoroaniline is used as a pharmaceutical intermediate.

InChI:InChI=1/C6H4BrF2N/c7-3-1-6(10)5(9)2-4(3)8/h1-2H,10H2

Upstream product

• 345-17-5 1-chloro-4-fluoro-2-nitrobenzene 
• 372-19-0 meta-fluoroaniline 
• 347-71-7 N-(2-chloro-5-fluorophenyl)acetamide 

Downstream Products

• 82875-86-3 2-chloro-5-fluorobenzene sulphonyl chloride 
• 917251-94-6 8-chloro-5-fluoro-2-(trifluoromethyl)quinolin-4-ol 
• 917251-76-4 8-chloro-5-fluoroquinoline 
• 701294-26-0 (2-chloro-5-fluorophenyl)thiourea 
• 1188930-02-0 2-chloro-5-fluoro-N-(2,4,6-trimethylphenyl)aniline 
• 737752-10-2 (2-chloro-5-fluorophenyl)hydrazine 

Relevant articles and documents

Catalyst-Controlled Regioselective Chlorination of Phenols and Anilines through a Lewis Basic Selenoether Catalyst

We report a highly efficient ortho-selective electrophilic chlorination of phenols utilizing a Lewis basic selenoether catalyst. The selenoether catalyst resulted in comparable selectivities to our previously reported bis-thiourea ortho-selective catalyst, with a catalyst loading as low as 1%. The new catalytic system also allowed us to extend this chemistry to obtain excellent ortho-selectivities for unprotected anilines. The selectivities of this reaction are up to >20:1 ortho/para, while the innate selectivities for phenols and anilines are approximately 1:4 ortho/para. A series of preliminary studies revealed that the substrates require a hydrogen-bonding moiety for selectivity.

CYCLIC AMIDES AND IMIDES HAVING SELECTIVE ANTAGONIST ACTIVITY AT ALPHA-1D ADRENERGIC RECEPTOR

Compounds (I) R and R1 independently = H or C1-C4 alkyl or together = (CH2)2-6, n=0 or 1, ...... is a single or a double bond, A=CO or CH2, A1 represents a CO or CH2 or CH, each R3 independently = H or C1-C4 alkyl, B is B1 or B2 (B2); Y=N or CH, R2 = halogen, C1-C4 alkyl or CN, R5 = halogen, C1-C4 alkyl, polyfluoroalkyl or NO2, R6 = H or halogen, m is 1 to 3, Z = O, S, NH or NMe) interact selectively with the alpha 1D subtype of the alpha 1 adrenergic receptor. This selectively makes these compounds useful agents in tissues particularly rich in alpha 1D adrenergic receptors, thus useful in reducing contractility of an unstable urinary bladder, in the treatment and prevention of atherosclerosis as they are inhibitors of noradrenaline-mediated cell proliferation in smooth muscles, and in reducing vascular adrenergic tone. The preparation of these compounds, their enantiomers, diastereoisomers, N-oxides and pharmaceutically acceptable salts, and pharmaceutical compositions containing them are also claimed.