(3aS,4R,6aR)-2,2-Dimethyl-5-(2-nitro-benzenesulfonyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-4-carbaldehyde

Base Information

Chemical Name:(3aS,4R,6aR)-2,2-Dimethyl-5-(2-nitro-benzenesulfonyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-4-carbaldehyde
CAS No.:570385-42-1
Molecular Formula:C₁₄H₁₆N₂O₇S
Molecular Weight:356.356
Hs Code.:

Synonyms:(3aS,4R,6aR)-2,2-Dimethyl-5-(2-nitro-benzenesulfonyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-4-carbaldehyde

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Chemical Property of (3aS,4R,6aR)-2,2-Dimethyl-5-(2-nitro-benzenesulfonyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-4-carbaldehyde

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Technology Process of (3aS,4R,6aR)-2,2-Dimethyl-5-(2-nitro-benzenesulfonyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-4-carbaldehyde

There total 7 articles about (3aS,4R,6aR)-2,2-Dimethyl-5-(2-nitro-benzenesulfonyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 570385-40-9
(S)-1-[(3aS,4S,6aR)-2,2-Dimethyl-5-(2-nitro-benzenesulfonyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-4-yl]-ethane-1,2-diol

: 570385-42-1
(3aS,4R,6aR)-2,2-Dimethyl-5-(2-nitro-benzenesulfonyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-4-carbaldehyde

Guidance literature:: With sodium periodate; silica gel; In dichloromethane; water;
DOI:10.1016/S0040-4039(03)00512-4

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 570385-42-1
(3aS,4R,6aR)-2,2-Dimethyl-5-(2-nitro-benzenesulfonyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-4-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / Et₃N / CH₂Cl₂

2: 100 percent / PPh₃; diethyl azodicarboxylate / tetrahydrofuran

3: 70 percent / TFA / tetrahydrofuran; H₂O

4: 96 percent / NaIO₄; silica gel / CH₂Cl₂; H₂O

With sodium periodate; silica gel; triethylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; 2: Mitsunobu reaction;
DOI:10.1016/S0040-4039(03)00512-4

Reference yield:

: 7306-64-1,14440-56-3,23262-80-8,27108-15-2,49561-21-9,67642-42-6
2,3,5,6-di-O-isopropylidene-D-mannono-1,4-lactone

: 570385-42-1
(3aS,4R,6aR)-2,2-Dimethyl-5-(2-nitro-benzenesulfonyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole-4-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / NH₃ / methanol

2: 76 percent / LiAlH₄ / tetrahydrofuran / Heating

3: 93 percent / Et₃N / CH₂Cl₂

4: 100 percent / PPh₃; diethyl azodicarboxylate / tetrahydrofuran

5: 70 percent / TFA / tetrahydrofuran; H₂O

6: 96 percent / NaIO₄; silica gel / CH₂Cl₂; H₂O

With sodium periodate; lithium aluminium tetrahydride; ammonia; silica gel; triethylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water; 4: Mitsunobu reaction;
DOI:10.1016/S0040-4039(03)00512-4