(3aS,4S,6aR)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-5-(2-nitro-benzenesulfonyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole

Base Information

Chemical Name:(3aS,4S,6aR)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-5-(2-nitro-benzenesulfonyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole
CAS No.:570385-37-4
Molecular Formula:C₁₈H₂₄N₂O₈S
Molecular Weight:428.463
Hs Code.:

Synonyms:(3aS,4S,6aR)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-5-(2-nitro-benzenesulfonyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole

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Chemical Property of (3aS,4S,6aR)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-5-(2-nitro-benzenesulfonyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole

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Technology Process of (3aS,4S,6aR)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-5-(2-nitro-benzenesulfonyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole

There total 5 articles about (3aS,4S,6aR)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-5-(2-nitro-benzenesulfonyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: N-{(4R,5S)-5-[(S)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl}-2-nitro-benzenesulfonamide

: 570385-37-4
(3aS,4S,6aR)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-5-(2-nitro-benzenesulfonyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;
DOI:10.1016/S0040-4039(03)00512-4

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 570385-37-4
(3aS,4S,6aR)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-5-(2-nitro-benzenesulfonyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / Et₃N / CH₂Cl₂

2: 100 percent / PPh₃; diethyl azodicarboxylate / tetrahydrofuran

With triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 2: Mitsunobu reaction;
DOI:10.1016/S0040-4039(03)00512-4

Reference yield:

: 7306-64-1,14440-56-3,23262-80-8,27108-15-2,49561-21-9,67642-42-6
2,3,5,6-di-O-isopropylidene-D-mannono-1,4-lactone

: 570385-37-4
(3aS,4S,6aR)-4-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-5-(2-nitro-benzenesulfonyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyrrole

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / NH₃ / methanol

2: 76 percent / LiAlH₄ / tetrahydrofuran / Heating

3: 93 percent / Et₃N / CH₂Cl₂

4: 100 percent / PPh₃; diethyl azodicarboxylate / tetrahydrofuran

With lithium aluminium tetrahydride; ammonia; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; 4: Mitsunobu reaction;
DOI:10.1016/S0040-4039(03)00512-4