2-(4-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)phenyl)-acetic acid

Base Information

• Chemical Name: 2-(4-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)phenyl)-acetic acid
• CAS No.: 1429744-76-2
• Molecular Formula: C₂₁H₁₉NO₄
• Molecular Weight: 349.386
• Mol file: 1429744-76-2.mol

Synonyms:2-(4-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)phenyl)-acetic acid

Chemical Property of 2-(4-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)phenyl)-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)phenyl)-acetic acid

There total 3 articles about 2-(4-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)phenyl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

4-aminophenylacetic acid (1197-55-3) + benzyloxy-2-methyl-4-pyrone → 2-(4-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)phenyl)-acetic acid (1429744-76-2)

Guidance literature:

With hydrogenchloride; In ethanol; water; for 12h; Reflux;

DOI:10.1039/c3dt50406a

Reference yield:

2-hydroxy-3-methyl-4H-pyran-4-one (61892-88-4) → 2-(4-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)phenyl)-acetic acid (1429744-76-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water / 12 h / Reflux

2: hydrogenchloride / water; ethanol / 12 h / Reflux

With hydrogenchloride; sodium hydroxide; In ethanol; water;

DOI:10.1039/c3dt50406a

Reference yield:

benzyl chloride (100-44-7) → 2-(4-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)phenyl)-acetic acid (1429744-76-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water / 12 h / Reflux

2: hydrogenchloride / water; ethanol / 12 h / Reflux

With hydrogenchloride; sodium hydroxide; In ethanol; water;

DOI:10.1039/c3dt50406a

upstream raw materials:

2-hydroxy-3-methyl-4H-pyran-4-one

benzyl chloride

4-aminophenylacetic acid

Downstream raw materials:

N-(4-(benzo[d]thiazol-2-ylmethyl)phenyl)-2-(4-(3-hydroxy-2-methyl-4-oxopyridin-1(4H)-yl)phenyl)acetamide

N-(4-(benzo[d]thiazol-2-yl)benzyl)-2-(4-(3-hydroxy-2-methyl-4-oxopyridin-1(4H)-yl)phenyl)acetamide

1-(4-(2-(benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-4-oxobutyl)-3-(benzyloxy)-2-methylpyridin-4(1H)-one

N-(4-(benzo[d]thiazol-2-yl)benzyl)-2-(4-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)phenyl)acetamide