1-(4-(2-(benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-4-oxobutyl)-3-(benzyloxy)-2-methylpyridin-4(1H)-one

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Chemical Name:1-(4-(2-(benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-4-oxobutyl)-3-(benzyloxy)-2-methylpyridin-4(1H)-one
CAS No.:1429744-81-9
Molecular Formula:C₂₈H₂₉N₃O₃S
Molecular Weight:487.623
Hs Code.:

Synonyms:1-(4-(2-(benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-4-oxobutyl)-3-(benzyloxy)-2-methylpyridin-4(1H)-one

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Chemical Property of 1-(4-(2-(benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-4-oxobutyl)-3-(benzyloxy)-2-methylpyridin-4(1H)-one

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Technology Process of 1-(4-(2-(benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-4-oxobutyl)-3-(benzyloxy)-2-methylpyridin-4(1H)-one

There total 5 articles about 1-(4-(2-(benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-4-oxobutyl)-3-(benzyloxy)-2-methylpyridin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1429744-76-2
2-(4-(3-(benzyloxy)-2-methyl-4-oxopyridin-1(4H)-yl)phenyl)-acetic acid

: 34211-04-6
(4-(benzo[d]thiazol-2-yl)phenyl)methanamine

: 1429744-81-9
1-(4-(2-(benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-4-oxobutyl)-3-(benzyloxy)-2-methylpyridin-4(1H)-one

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1039/c3dt50406a

Reference yield:

: 137-07-5
2-amino-benzenethiol

: 1429744-81-9
1-(4-(2-(benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-4-oxobutyl)-3-(benzyloxy)-2-methylpyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: polyphosphoric acid (PPA) / 4 h / 220 °C / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 12 h / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1039/c3dt50406a

Reference yield:

: 61892-88-4
2-hydroxy-3-methyl-4H-pyran-4-one

: 1429744-81-9
1-(4-(2-(benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-4-oxobutyl)-3-(benzyloxy)-2-methylpyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water / 12 h / Reflux

2: hydrogenchloride / water; ethanol / 12 h / Reflux

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 12 h / 20 °C

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In ethanol; dichloromethane; water;
DOI:10.1039/c3dt50406a