(R)-3-((bis(3-fluorophenyl)methoxy)carbonylamino)-1-(2-phenoxyethyl)-1-azoniabicyclo[2.2.2]octane bromide

Base Information

Chemical Name:(R)-3-((bis(3-fluorophenyl)methoxy)carbonylamino)-1-(2-phenoxyethyl)-1-azoniabicyclo[2.2.2]octane bromide
CAS No.:1404054-52-9
Molecular Formula:Br*C₂₉H₃₁F₂N₂O₃
Molecular Weight:573.478
Hs Code.:

Synonyms:(R)-3-((bis(3-fluorophenyl)methoxy)carbonylamino)-1-(2-phenoxyethyl)-1-azoniabicyclo[2.2.2]octane bromide

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Chemical Property of (R)-3-((bis(3-fluorophenyl)methoxy)carbonylamino)-1-(2-phenoxyethyl)-1-azoniabicyclo[2.2.2]octane bromide

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Technology Process of (R)-3-((bis(3-fluorophenyl)methoxy)carbonylamino)-1-(2-phenoxyethyl)-1-azoniabicyclo[2.2.2]octane bromide

There total 3 articles about (R)-3-((bis(3-fluorophenyl)methoxy)carbonylamino)-1-(2-phenoxyethyl)-1-azoniabicyclo[2.2.2]octane bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1404054-16-5
(R)-bis(3-fluorophenyl)methyl quinuclidin-3-ylcarbamate

: 589-10-6
phenoxyethyl bromide

: 1404054-52-9
(R)-3-((bis(3-fluorophenyl)methoxy)carbonylamino)-1-(2-phenoxyethyl)-1-azoniabicyclo[2.2.2]octane bromide

Guidance literature:: (R)-bis(3-fluorophenyl)methyl quinuclidin-3-ylcarbamate; phenoxyethyl bromide; In ethyl acetate; at 20 - 100 ℃; Microwave irradiation;

With potassium iodide; at 120 ℃; for 1h; Microwave irradiation;

Reference yield:

: 6530-09-2,119904-90-4,120538-52-5,123536-14-1,124577-62-4,126358-22-3,137661-30-4,137661-31-5
(3R)-quinuclidin-3-amine dihydrochloride

: 1404054-52-9
(R)-3-((bis(3-fluorophenyl)methoxy)carbonylamino)-1-(2-phenoxyethyl)-1-azoniabicyclo[2.2.2]octane bromide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / water; methanol / 1 h / 20 °C

1.2: 7 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

2.2: 48 h / 20 °C

3.1: ethyl acetate / 20 - 100 °C / Microwave irradiation

3.2: 1 h / 120 °C / Microwave irradiation

With sodium hydride; sodium hydrogencarbonate; In methanol; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 98586-21-1
bis(3-fluorophenyl)methanol

: 1404054-52-9
(R)-3-((bis(3-fluorophenyl)methoxy)carbonylamino)-1-(2-phenoxyethyl)-1-azoniabicyclo[2.2.2]octane bromide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / water; methanol / 1 h / 20 °C

1.2: 16 h / 20 °C

1.3: 48 h / 20 °C

2.1: ethyl acetate / 20 °C / Microwave irradiation

2.2: 1.25 h / 100 - 120 °C / Microwave irradiation

With sodium hydrogencarbonate; In methanol; water; ethyl acetate;