spiro[morpholine-4′,2-(4-phenyl-3a,4-dihydrobenzo[f]isoindolinium)] bromide

Base Information

• Chemical Name: spiro[morpholine-4′,2-(4-phenyl-3a,4-dihydrobenzo[f]isoindolinium)] bromide
• CAS No.: 1416470-12-6
• Molecular Formula: Br*C₂₂H₂₄NO
• Molecular Weight: 398.343
• Mol file: 1416470-12-6.mol

Synonyms:spiro[morpholine-4′,2-(4-phenyl-3a,4-dihydrobenzo[f]isoindolinium)] bromide

Chemical Property of spiro[morpholine-4′,2-(4-phenyl-3a,4-dihydrobenzo[f]isoindolinium)] bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of spiro[morpholine-4′,2-(4-phenyl-3a,4-dihydrobenzo[f]isoindolinium)] bromide

There total 2 articles about spiro[morpholine-4′,2-(4-phenyl-3a,4-dihydrobenzo[f]isoindolinium)] bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-(3-Phenylpropen-2-yl)-N-(3-phenylpropyn-2-yl)morpholinium bromide → spiro[morpholine-4′,2-(4-phenyl-3a,4-dihydrobenzo[f]isoindolinium)] bromide (1416470-12-6)

Guidance literature:

With potassium hydroxide; In water; at 40 - 80 ℃;

DOI:10.1007/s10593-013-1375-1

Reference yield:

4-(3-phenyl-prop-2-ynyl)-morpholine (1017-73-8) → spiro[morpholine-4′,2-(4-phenyl-3a,4-dihydrobenzo[f]isoindolinium)] bromide (1416470-12-6)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether; acetonitrile

2: potassium hydroxide / water; ethanol / 5 - 6 h / 90 - 92 °C

With potassium hydroxide; In diethyl ether; ethanol; water; acetonitrile;

DOI:10.1007/s10593-012-1138-4

Reference yield:

spiro[morpholine-4′,2-(4-phenyl-3a,4-dihydrobenzo[f]isoindolinium)] bromide (1416470-12-6) → N-[(3-Methyl-1-phenyl-2-naphthyl)methyl]morpholine (1416470-22-8) + 3-(Dimethylaminomethyl)-2-methyl-1-phenylnaphthalene

Guidance literature:

With potassium hydroxide; In ethanol; water; at 110 - 145 ℃; Overall yield = 68 %; Overall yield = 1.3 g;

DOI:10.1007/s10593-012-1138-4

upstream raw materials:

4-(3-phenyl-prop-2-ynyl)-morpholine

Downstream raw materials:

N-[(3-Methyl-1-phenyl-2-naphthyl)methyl]morpholine