4-(3-Phenylprop-2-ynyl)morpholine

Base Information

• Chemical Name: 4-(3-Phenylprop-2-ynyl)morpholine
• CAS No.: 1017-73-8
• Molecular Formula: C13H15NO
• Molecular Weight: 201.268
• DSSTox Substance ID: DTXSID50354560
• Nikkaji Number: J1.087.299E
• Wikidata: Q82132784
• ChEMBL ID: CHEMBL1619572
• Mol file: 1017-73-8.mol

Synonyms:1017-73-8;4-(3-phenylprop-2-yn-1-yl)morpholine;Morpholine, 4-(3-phenyl-2-propyn-1-yl)-;4-(3-phenylprop-2-ynyl)morpholine;CBMicro_023410;ChemDiv2_003404;Oprea1_242828;Oprea1_345272;CBDivE_010303;SCHEMBL3634873;CHEMBL1619572;DTXSID50354560;HMS1378K16;CCG-11085;STK946024;AKOS000629923;NCGC00320642-01;3-(morpholin-4-yl)-1-phenyl-prop-1-yne;BIM-0023479.P001;VU0310294-2;AB00638326-08;F3379-1091;Z111656878;InChI=1/C13H15NO/c1-2-5-13(6-3-1)7-4-8-14-9-11-15-12-10-14/h1-3,5-6H,8-12H

Chemical Property of 4-(3-Phenylprop-2-ynyl)morpholine

Chemical Property:

• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 201.115364102
• Heavy Atom Count: 15
• Complexity: 238

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1COCCN1CC#CC2=CC=CC=C2

Technology Process of 4-(3-Phenylprop-2-ynyl)morpholine

There total 20 articles about 4-(3-Phenylprop-2-ynyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + phenylacetylene (536-74-3) → 4-(3-phenyl-prop-2-ynyl)-morpholine (1017-73-8)

Guidance literature:

With polymer-supported L-proline copper complex; In dimethyl sulfoxide; at 20 ℃; for 2h;

Reference yield: 98.0%

morpholine (110-91-8,99108-56-2) + phenylpropyolic acid (637-44-5) → 4-(3-phenyl-prop-2-ynyl)-morpholine (1017-73-8)

Guidance literature:

With formaldehyd; In acetonitrile; at 65 ℃; for 3h; Solvent; Temperature; Reagent/catalyst; Concentration;

DOI:10.1021/ol401358t

Reference yield: 98.0%

4-(morpholinomethyl)morpholine (5625-90-1) + phenylacetylene (536-74-3) → 4-(3-phenyl-prop-2-ynyl)-morpholine (1017-73-8)

Guidance literature:

With copper(l) chloride; at 80 ℃; for 6h; Under argon;

DOI:10.1134/S1070428010010021

upstream raw materials:

morpholine

formaldehyd

phenylacetylene

1-(4-morpholinomethyl)-1H-benzotriazole

Downstream raw materials:

(E)-3-phenylpropenal

(E)-β-methylcinnamaldehyde

4-(3-Phenyl-propa-1,2-dienyl)-morpholine

N-(3-phenylbuta-1,2-dienyl)morpholine