C₄₅H₇₃N₅O₁₂Si

Base Information

Chemical Name:C₄₅H₇₃N₅O₁₂Si
CAS No.:1515606-22-0
Molecular Formula:C₄₅H₇₃N₅O₁₂Si
Molecular Weight:904.186
Hs Code.:

C<sub>45</sub>H<sub>73</sub>N<sub>5</sub>O<sub>12</sub>Si

Synonyms:C₄₅H₇₃N₅O₁₂Si

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Chemical Property of C₄₅H₇₃N₅O₁₂Si

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Technology Process of C₄₅H₇₃N₅O₁₂Si

There total 17 articles about C₄₅H₇₃N₅O₁₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1515605-46-5
2-propenyl 2-(2-isocyano-N-methylacetamido)acetate

: 1515605-49-8
C₁₄H₂₉NOSi

: 1515605-47-6
N-Cbz-D-Ser(N-Boc-N-Me-Val)-OH

: 1515605-42-1
N-Cbz-D-Ser[N-Me-Boc-Val]-(S)-β-L-triisopropylsilyloxy-Pip-Gly-Sar allyl ester

: 1515606-22-0
C₄₅H₇₃N₅O₁₂Si

Guidance literature:: With triethylphosphine; In toluene; at 70 ℃; for 48h; Overall yield = 68 %; Overall yield = 550 mg; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol403319m

Reference yield:

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 1515605-42-1
N-Cbz-D-Ser[N-Me-Boc-Val]-(S)-β-L-triisopropylsilyloxy-Pip-Gly-Sar allyl ester

: 1515606-22-0
C₄₅H₇₃N₅O₁₂Si

Guidance literature:: Multi-step reaction with 8 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2.1: borane-THF / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

2.2: 12 h / 0 - 20 °C

3.1: triethylamine; trimethylamine hydrochloride / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

4.1: tetra-(n-butyl)ammonium iodide; sodium azide / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

5.1: zinc dibromide / methanol; dichloromethane / 30 h / 0 - 20 °C / Inert atmosphere

6.1: triethylamine; sulfur trioxide pyridine complex; dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

7.1: triethylphosphine / toluene; tetrahydrofuran / 30 h / 0 - 20 °C / Inert atmosphere

8.1: triethylphosphine / toluene / 48 h / 70 °C / Inert atmosphere

With 2,6-dimethylpyridine; sodium azide; borane-THF; sulfur trioxide pyridine complex; trimethylamine hydrochloride; tetra-(n-butyl)ammonium iodide; dimethyl sulfoxide; triethylamine; zinc dibromide; triethylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 8.1: |Ugi Condensation;
DOI:10.1021/ol403319m

Reference yield:

: 1515605-77-2
(S)-5-azido-2-triisopropylsilyloxy-1-pentanol

: 1515605-42-1
N-Cbz-D-Ser[N-Me-Boc-Val]-(S)-β-L-triisopropylsilyloxy-Pip-Gly-Sar allyl ester

: 1515606-22-0
C₄₅H₇₃N₅O₁₂Si

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; sulfur trioxide pyridine complex; dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

2: triethylphosphine / toluene; tetrahydrofuran / 30 h / 0 - 20 °C / Inert atmosphere

3: triethylphosphine / toluene / 48 h / 70 °C / Inert atmosphere

With sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; triethylphosphine; In tetrahydrofuran; toluene; 3: |Ugi Condensation;
DOI:10.1021/ol403319m