3-(4-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazin-1-yl)butyl)indolin-2-one

Base Information

Chemical Name:3-(4-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazin-1-yl)butyl)indolin-2-one
CAS No.:1422513-04-9
Molecular Formula:C₂₈H₃₈BN₃O₃
Molecular Weight:475.439
Hs Code.:

Synonyms:3-(4-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazin-1-yl)butyl)indolin-2-one

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Chemical Property of 3-(4-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazin-1-yl)butyl)indolin-2-one

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Technology Process of 3-(4-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazin-1-yl)butyl)indolin-2-one

There total 2 articles about 3-(4-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazin-1-yl)butyl)indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1422513-03-8
3-(4-(4-(4-bromophenyl)piperazin-1-yl)butyl)indolin-2-one

: 73183-34-3
bis(pinacol)diborane

: 1422513-04-9
3-(4-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazin-1-yl)butyl)indolin-2-one

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 100 ℃; for 12h;
DOI:10.1016/j.tetlet.2012.11.001

Reference yield:

: 797051-90-2
methanesulfonic acid 4-(2-oxo-2,3-dihydro-1H-indol-3-yl)butyl ester

: 66698-28-0
1-(4-bromophenyl)piperazine

: 1422513-04-9
3-(4-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazin-1-yl)butyl)indolin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / 130 °C

2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 12 h / 100 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; In 1,4-dioxane; 2: |Miyaura Borylation Reaction;
DOI:10.1016/j.tetlet.2012.11.001

Reference yield:

: 54245-42-0
[11C]methyl iodide

: 1422513-04-9
3-(4-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazin-1-yl)butyl)indolin-2-one

: 1422512-93-3
C₂₂⁽¹¹⁾CH₂₉N₃O

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; tris-(o-tolyl)phosphine; In water; N,N-dimethyl-formamide; at 60 ℃;
DOI:10.1016/j.tetlet.2012.11.001