4-hydroxy-3-methylcinnamic acid

Base Information

• Chemical Name: 4-hydroxy-3-methylcinnamic acid
• CAS No.: 19780-88-2
• Molecular Formula: C₁₀H₁₀O₃
• Molecular Weight: 178.188
• Mol file: 19780-88-2.mol

Synonyms:4-hydroxy-3-methylcinnamic acid

Chemical Property of 4-hydroxy-3-methylcinnamic acid

Chemical Property:

Purity/Quality:

4-HYDROXY-3-METHYLCINNAMIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-hydroxy-3-methylcinnamic acid

There total 1 articles about 4-hydroxy-3-methylcinnamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

malonic acid (141-82-2) + 4-hydroxy-3-methyl-benzaldehyde (15174-69-3) → 4-hydroxy-3-methylcinnamic acid (19780-88-2)

Guidance literature:

With piperidine; pyridine; at 100 ℃;

Reference yield: 93.0%

4-hydroxy-3-methylcinnamic acid (19780-88-2) → 3-methyl-4-hydroxystyrene (45803-83-6)

Guidance literature:

In N,N-dimethyl-formamide; at 130 ℃; for 0.5h;

Reference yield: 78.0%

4-hydroxy-3-methylcinnamic acid (19780-88-2) + 4,5-dibromo-1H-pyrrole-2-carbohydrazide (50371-65-8) → 4-(2-(5-(4,5-dibromo-1H-pyrrol-2-yl)-1,3,4-oxadiazol-2-yl)vinyl)-2-methylphenol

Guidance literature:

With trichlorophosphate; for 20h; Reflux; Inert atmosphere; Molecular sieve;

DOI:10.1016/j.bmcl.2012.08.061

upstream raw materials:

malonic acid

4-hydroxy-3-methyl-benzaldehyde

Downstream raw materials:

3-methyl-4-hydroxystyrene

(S)-4-(1-hydroxyethyl)-2-methylphenol

(R)-4-(1-hydroxyethyl)-2-methylphenol

Refernces