2-((tert-butyldimethylsilyl)oxy)-1-(4-(trifluoromethyl)phenyl)ethanone

Base Information

Chemical Name:2-((tert-butyldimethylsilyl)oxy)-1-(4-(trifluoromethyl)phenyl)ethanone
CAS No.:1312718-93-6
Molecular Formula:C₁₅H₂₁F₃O₂Si
Molecular Weight:318.411
Hs Code.:

Synonyms:2-((tert-butyldimethylsilyl)oxy)-1-(4-(trifluoromethyl)phenyl)ethanone

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Chemical Property of 2-((tert-butyldimethylsilyl)oxy)-1-(4-(trifluoromethyl)phenyl)ethanone

Chemical Property:

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Technology Process of 2-((tert-butyldimethylsilyl)oxy)-1-(4-(trifluoromethyl)phenyl)ethanone

There total 3 articles about 2-((tert-butyldimethylsilyl)oxy)-1-(4-(trifluoromethyl)phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 163089-34-7
N-methoxy-N-methyl-2-(1,1,2,2-tetramethyl-1-silapropoxy)acetamide

: 402-43-7
p-trifluoromethylphenyl bromide

: 1312718-93-6
2-((tert-butyldimethylsilyl)oxy)-1-(4-(trifluoromethyl)phenyl)ethanone

Guidance literature:: p-trifluoromethylphenyl bromide; With magnesium; ethylene dibromide; In tetrahydrofuran; at 20 ℃; for 0.666667h; Inert atmosphere;

N-methoxy-N-methyl-2-(1,1,2,2-tetramethyl-1-silapropoxy)acetamide; In tetrahydrofuran; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.tetasy.2011.01.011

Reference yield:

: 1151770-62-5
tert-butyldimethyl((1-(4-(trifluoromethyl)phenyl)vinyl)oxy)silane

: 1312718-93-6
2-((tert-butyldimethylsilyl)oxy)-1-(4-(trifluoromethyl)phenyl)ethanone

Guidance literature:: With 2,2,2-Trifluoroacetophenone; dihydrogen peroxide; In acetonitrile; tert-butyl alcohol; at 20 ℃; for 1h; Green chemistry;
DOI:10.1039/c6ob00036c

Reference yield:

: 709-63-7
1-(4-trifluoromethylphenyl)ethanone

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1312718-93-6
2-((tert-butyldimethylsilyl)oxy)-1-(4-(trifluoromethyl)phenyl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 2.5 h / -78 - 85 °C / Inert atmosphere; Green chemistry

2: 2,2,2-Trifluoroacetophenone; dihydrogen peroxide / acetonitrile; tert-butyl alcohol / 1 h / 20 °C / Green chemistry

With 2,2,2-Trifluoroacetophenone; dihydrogen peroxide; sodium hydride; In tetrahydrofuran; acetonitrile; tert-butyl alcohol;
DOI:10.1039/c6ob00036c