(4aR,6S,7R,8aS)-2,2-di(tert-butyl)-7-{1-[3-(4-methoxybenzyloxy)propyl]vinyloxy}-6-methyl-6-(2-methylallyl)-4,4a,6,7,8,8a-hexahydro-1,3,5-trioxa-2-silanaphthalene

Base Information

Chemical Name:(4aR,6S,7R,8aS)-2,2-di(tert-butyl)-7-{1-[3-(4-methoxybenzyloxy)propyl]vinyloxy}-6-methyl-6-(2-methylallyl)-4,4a,6,7,8,8a-hexahydro-1,3,5-trioxa-2-silanaphthalene
CAS No.:511256-86-3
Molecular Formula:C₃₂H₅₂O₆Si
Molecular Weight:560.847
Hs Code.:

(4aR,6S,7R,8aS)-2,2-di(tert-butyl)-7-{1-[3-(4-methoxybenzyloxy)propyl]vinyloxy}-6-methyl-6-(2-methylallyl)-4,4a,6,7,8,8a-hexahydro-1,3,5-trioxa-2-silanaphthalene

Synonyms:(4aR,6S,7R,8aS)-2,2-di(tert-butyl)-7-{1-[3-(4-methoxybenzyloxy)propyl]vinyloxy}-6-methyl-6-(2-methylallyl)-4,4a,6,7,8,8a-hexahydro-1,3,5-trioxa-2-silanaphthalene

Suppliers and Price of (4aR,6S,7R,8aS)-2,2-di(tert-butyl)-7-{1-[3-(4-methoxybenzyloxy)propyl]vinyloxy}-6-methyl-6-(2-methylallyl)-4,4a,6,7,8,8a-hexahydro-1,3,5-trioxa-2-silanaphthalene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4aR,6S,7R,8aS)-2,2-di(tert-butyl)-7-{1-[3-(4-methoxybenzyloxy)propyl]vinyloxy}-6-methyl-6-(2-methylallyl)-4,4a,6,7,8,8a-hexahydro-1,3,5-trioxa-2-silanaphthalene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4aR,6S,7R,8aS)-2,2-di(tert-butyl)-7-{1-[3-(4-methoxybenzyloxy)propyl]vinyloxy}-6-methyl-6-(2-methylallyl)-4,4a,6,7,8,8a-hexahydro-1,3,5-trioxa-2-silanaphthalene

There total 11 articles about (4aR,6S,7R,8aS)-2,2-di(tert-butyl)-7-{1-[3-(4-methoxybenzyloxy)propyl]vinyloxy}-6-methyl-6-(2-methylallyl)-4,4a,6,7,8,8a-hexahydro-1,3,5-trioxa-2-silanaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 511256-85-2
(4aR,6S,7R,8aS)-4-(4-methoxybenzyloxy)butyric acid 2,2-di(tert-butyl)-6-methyl-6-(2-methylallyl)-4,4a,6,7,8,8a-hexahydro-1,3,5-trioxa-2-silanaphthalen-7-yl ester

: 74-95-3
1,1-dibromomethane

: 511256-86-3
(4aR,6S,7R,8aS)-2,2-di(tert-butyl)-7-{1-[3-(4-methoxybenzyloxy)propyl]vinyloxy}-6-methyl-6-(2-methylallyl)-4,4a,6,7,8,8a-hexahydro-1,3,5-trioxa-2-silanaphthalene

Guidance literature:: With N,N,N,N,-tetramethylethylenediamine; titanium tetrachloride; zinc; lead(II) chloride; In tetrahydrofuran; dichloromethane; for 2h; Heating;
DOI:10.1021/ol034100w

Reference yield: 83.0%

: 511256-96-5
C₃₃H₅₂O₈S₂Si

: 74-95-3
1,1-dibromomethane

: 511256-86-3
(4aR,6S,7R,8aS)-2,2-di(tert-butyl)-7-{1-[3-(4-methoxybenzyloxy)propyl]vinyloxy}-6-methyl-6-(2-methylallyl)-4,4a,6,7,8,8a-hexahydro-1,3,5-trioxa-2-silanaphthalene

Guidance literature:: C₃₃H₅₂O₈S₂Si; With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; at 80 ℃; for 1.5h;

1,1-dibromomethane; With N,N,N,N,-tetramethylethylenediamine; titanium tetrachloride; zinc; lead(II) chloride; In tetrahydrofuran; at 65 ℃; Further stages.;
DOI:10.1002/chem.200500993

Reference yield:

: 191593-14-3
4,6-O-di(tert-butyl)silanediyl-D-glucal

: 511256-86-3
(4aR,6S,7R,8aS)-2,2-di(tert-butyl)-7-{1-[3-(4-methoxybenzyloxy)propyl]vinyloxy}-6-methyl-6-(2-methylallyl)-4,4a,6,7,8,8a-hexahydro-1,3,5-trioxa-2-silanaphthalene

Guidance literature:: Multi-step reaction with 10 steps

1.1: 97 percent / imidazole / dimethylformamide / 12 h / 20 °C

2.1: t-BuLi / tetrahydrofuran; pentane / 0.5 h / 0 °C

2.2: 95 percent / tetrahydrofuran; pentane / -70 - 20 °C

3.1: dimethyl dioxirane / CH₂Cl₂ / 0.5 h / -65 °C

3.2: 90 percent / CH₂Cl₂ / 0.25 h / -65 °C

4.1: 95 percent / NaH / hexamethylphosphoric acid triamide / 0.5 h / 0 °C

5.1: 86 percent / i-Pr₂NEt / CH₂Cl₂ / 3 h / -65 - 20 °C

6.1: 93 percent / DCC; DMAP / CH₂Cl₂ / 14 h / 20 °C

7.1: 100 percent / glacial AcOH / methanol; H₂O / 6 h / 0 °C

8.1: NaH / 4 h / 20 °C

8.2: 86 percent / 48 h / 20 °C

9.1: 19.4 mg / n-Bu₃SnH; AIBN / toluene / 2 h / 110 °C

10.1: 100 percent / TiCl₄; TMEDA; Zn / PbCl₂ / tetrahydrofuran; CH₂Cl₂ / 2 h / Heating

With 1H-imidazole; dmap; 2,2'-azobis(isobutyronitrile); N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; tri-n-butyl-tin hydride; 3,3-dimethyldioxirane; titanium tetrachloride; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; zinc; lead(II) chloride; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water; N,N-dimethyl-formamide; toluene; pentane;
DOI:10.1021/ol034100w